Expert Tenant Broker
We represent you, not the landlord

Rent/Lease Office 222 E 41st St

Lease Office 222 E 41st St

Rent Sublease Office at 222 E 41st St

Nearby Sublease office Spaces for Rent

Address $ / SF / Yr SF Monthly Rent
Fifth Ave & East 44th Street $ 65
13,500
$ 73,125
Third Ave & East 39th Street $ 35
49,100
$ 143,208
Lexington Ave & East 43rd Street $ 55
12,900
$ 59,125
5th Ave & East 44th Street $ 70.5
9,600
$ 56,400
Park Ave & East 45th Street $ 98
9,700
$ 79,216
E 42nd St & Lexington Avenue $ 40
55,700
$ 185,666
Address $ / SF / Yr SF Monthly Rent
Park Ave & East 39th Street $ 99
4,200
$ 34,650
Fifth Ave & East 44th Street $ 50
3,300
$ 13,750
E 42nd St & Lexington Avenue $ 49
4,800
$ 19,600
Lexington Ave & East 41st Street $ 63
3,800
$ 19,950
5th Ave & East 44th Street $ 71
7,000
$ 41,416
Park Ave & East 40th Street $ 66
4,300
$ 23,650
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & East 45th Street $ 50
2,100
$ 8,750
Park Ave & East 40th Street $ 67.5
2,000
$ 11,250
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & East 45th Street $ 40
10,300
$ 34,333
Lexington Ave & East 41st Street $ 24.75
7,300
$ 15,056
Address $ / SF / Yr SF Monthly Rent
E 42nd St & Park Avenue $ 42
5,100
$ 17,850
Fifth Ave & East 44th Street $ 51.5
3,300
$ 14,162
E 42nd St & Lexington Avenue $ 52
4,800
$ 20,800
Lexington Ave & East 41st Street $ 27.25
5,600
$ 12,716
Madison Ave & East 40th Street $ 58.75
4,200
$ 20,562
E 41st St & Fifth Avenue $ 47
2,700
$ 10,575
Fifth Ave & East 45th Street $ 54
3,400
$ 15,300
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & East 45th Street $ 51.5
2,100
$ 9,012
Lexington Ave & East 40th Street $ 41
2,100
$ 7,175
Address $ / SF / Yr SF Monthly Rent
Address $ / SF / Yr SF Monthly Rent
Address $ / SF / Yr SF Monthly Rent
Type of Space Class A/month Class B/month Class C/month
Windowed office/person
Interior office/person
Team Rooms
Suites

Nearby office Spaces for Rent

Address $ / SF / Yr SF Monthly Rent
Vanderbilt Ave & East 43rd Street $ 125
15,800
$ 164,583
Fifth Ave & East 46th Street $ 69
11,400
$ 65,550
Park Ave & East 41st Street $ 175
12,200
$ 177,916
Lexington Ave & East 42nd Street $ 69
7,400
$ 42,550
Third Ave & East 40th Street $ 60
27,700
$ 138,500
Park Ave & East 39th Street $ 105
12,400
$ 108,500
E 42nd St & Lexington Avenue $ 69
28,500
$ 163,875
Fifth Ave & East 40th Street $ 85
11,200
$ 79,333
Madison Ave & East 45th Street $ 85
14,200
$ 100,583
E 42nd St & Madison Avenue $ 84
12,700
$ 88,900
Address $ / SF / Yr SF Monthly Rent
Park Ave & East 40th Street $ 98
3,200
$ 26,133
E 45th St & Lexington Avenue $ 81
4,300
$ 29,025
Lexington Ave & East 42nd Street $ 67
4,000
$ 22,333
Third Ave & East 40th Street $ 63
3,600
$ 18,900
Third Ave & East 42nd Street $ 70
5,500
$ 32,083
E 42nd St & Lexington Avenue $ 58
4,100
$ 19,816
Vanderbilt Ave & East 44th Street $ 49
5,300
$ 21,641
Third Ave & East 41st Street $ 55
5,100
$ 23,375
Third Ave & East 41st Street $ 70
4,800
$ 28,000
Third Ave & Between East 44th Street $ 65
4,800
$ 26,000
Third Ave & East 46th Street $ 62
4,100
$ 21,183
Third Ave & East 39th Street $ 70
4,700
$ 27,416
Address $ / SF / Yr SF Monthly Rent
E 45th St & Lexington Avenue $ 75
2,400
$ 15,000
Lexington Ave & East 42nd Street $ 61
1,500
$ 7,625
Park Ave & East 41st Street $ 85
2,300
$ 16,291
Lexington Ave & East 41st Street $ 57
1,500
$ 7,125
Third Ave & East 41st Street $ 55
1,700
$ 7,791
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & East 42nd Street $ 58
7,400
$ 35,766
E 42nd St & Park Avenue $ 59
9,700
$ 47,691
E 42nd St & Lexington Avenue $ 65
8,400
$ 45,500
Madison Ave & East 40th Street $ 65.5
14,600
$ 79,691
Vanderbilt Ave & East 44th Street $ 79
8,100
$ 53,325
Fifth Ave & East 45th Street $ 68
7,900
$ 44,766
E 44th St & Third Avenue $ 58
8,400
$ 40,600
E 45th St & Third Avenue $ 48
7,100
$ 28,400
Madison Ave & East 40th Street $ 59
16,000
$ 78,666
Address $ / SF / Yr SF Monthly Rent
E 41st St & Fifth Avenue $ 59
5,300
$ 26,058
E 45th St & Third Avenue $ 48
5,000
$ 20,000
Madison Ave & East 40th Street $ 56
6,900
$ 32,200
E 44th St & Third Avenue $ 48
4,500
$ 18,000
E 41st St & Fifth Avenue $ 50
4,000
$ 16,666
E 42nd St & Park Avenue $ 66
6,700
$ 36,850
Madison Ave & East 40th Street $ 45
3,500
$ 13,125
Madison Ave & East 40th Street $ 75
3,600
$ 22,500
Madison Ave & East 41st Street $ 56
5,700
$ 26,600
Madison Ave & East 41st Street $ 61
2,600
$ 13,216
Lexington Ave & East 41st Street $ 60
3,700
$ 18,500
Vanderbilt Ave & East 44th Street $ 50
4,000
$ 16,666
Fifth Ave & East 45th Street $ 84
6,800
$ 47,600
Third Ave & Between East 44th Street $ 66
4,800
$ 26,400
E 42nd St & Lexington Avenue $ 55
3,300
$ 15,125
Address $ / SF / Yr SF Monthly Rent
E 46th St & Fifth Avenue $ 132
2,000
$ 22,000
E 45th St & Third Avenue $ 47
1,700
$ 6,658
Madison Ave & East 41st Street $ 55
2,000
$ 9,166
Lexington Ave & East 40th Street $ 43
2,100
$ 7,525
Fifth Ave & East 42nd Street $ 60
1,600
$ 8,000
Lexington Ave & East 44th Street $ 55
1,500
$ 6,875
E 42nd St & Lexington Avenue $ 61
2,200
$ 11,183
E 42nd St & Madison Avenue $ 69
2,100
$ 12,075
Second Ave & East 43rd Street $ 59
2,300
$ 11,308
Madison Ave & East 39th Street $ 52
1,900
$ 8,233
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & Between East 42nd Street $ 84
9,200
$ 64,400
Fifth Ave & East 39th Street $ 52
7,300
$ 31,633
E 39th St & Fifth Avenue $ 39.5
7,900
$ 26,004
Address $ / SF / Yr SF Monthly Rent
Fifth Ave & Between East 42nd Street $ 83.5
6,000
$ 41,750
E 40th St & Lexington Avenue $ 48.5
3,000
$ 12,125
Address $ / SF / Yr SF Monthly Rent
E 40th St & Lexington Avenue $ 50.5
1,600
$ 6,733

Retail Spaces for Rent at 222 E 41st St

Rent Retail 222 E 41st St

Rent Medical Space at 222 E 41st St

Office Tenants Rented / Leased 222 East 41st Street
  • NYU Langone Medical leased 390,000 SF
  • Jones Day leased 11,972 SF
  • Icon Parking Systems leased 1,000 SF
  • NYU Langone Medical Cen… leased 385,015 SF
  • Lavra, Paul, Christian leased 0 SF
  • NYU Langone Neurology… leased 0 SF
Nearby Office Tenants Leased
  • The United Nations leased 120,000 SF at 730 Third Ave
  • Convene leased 116,000 SF at 530 Fifth Avenue
  • WeWork leased 115,000 SF at 149 Madison Avenue
  • McLaughlin & Stern leased 112,000 SF at 260 Madison Avenue
  • TBWA Worldwide leased 107,308 SF at 488 Madison Ave
  • KPMG LLP leased 102,979 SF at 560 Lexington Ave
  • Bonnier Corp. leased 100,750 SF at 2 Park Ave
  • Crain Communications leased 100,000 SF at 711 Third Ave
  • Pernod Ricard USA, Inc. leased 97,444 SF at 250 Park Ave
  • W. W. Norton & Company leased 95,000 SF at 500 Fifth Avenue
Nearby Retail Tenants Leased
  • Le Pain Quotidien leased 6,050 SF at 3 Park Ave
  • Brooks Brothers leased 6,000 SF at 11 East 44th St
  • National Basketball Association leased 6,000 SF at 590 Fifth Ave
  • Designer Bargain Store leased 5,800 SF at 417 Fifth Ave
  • Fine & Rare leased 5,702 SF at 9 East 37th Street
  • Lex Dees Stores Inc. leased 5,372 SF at 420 Lexington Ave
  • Sephora leased 5,316 SF at 300 Madison Avenue
  • Wells Fargo leased 4,700 SF at 535 Madison Avenue
  • Joseph Abboud leased 4,600 SF at 424 Madison Ave
  • Daum Inc.; Haviland Inc. leased 4,500 SF at 499 Park Ave
$ / SF SF Monthly Rent
Please notify me when a new space is available
Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 222 East 41st Street. This trend is projected to continue. Opportunities for subleases remain available at 222 East 41st Street and in the nearby Grand Central neighborhood.
Find My Space!
222 East 41st Street nyc
Thank you! we will be in touch.

Before you go please fill:


Search all rental options at 222 E 41st St

Why Optimal Spaces Tenant Broker

  • Lease negotiation: full terms, renewals, expansion options
  • Cost analysis, inventory identification, negotiating scope
  • Risk mitigation against hidden pitfalls

Cost Savings

  • Negotiate 30+ leasing points to prevent hidden costs
  • Save 10–15% on total leasing costs
  • Save 100–200 hours filtering unviable spaces
  • Property access via broker databases and networks (off-market, subleases, future availability)

Alone or With Other Brokers

  • Managing agents owe fiduciary duty to landlords, seeking maximum price and terms rather than tenant savings.
  • Inherent conflict of interest as most brokers represent landlords
  • Risk of weaker terms and overlooked hidden costs
  • Heavy workload falls on you while best spaces are missed

222 East 41st Street Property Overview

Building Address: 222 E 41st St, New York NY 10017
Building Alternate Address: 222 E 41st St
Zip Code:10017
Neighborhood:Grand Central
Borough:Manhattan
Stories:25
Year Built:2002
Building Class:A
Block & lot:01314-0000

222 East 41st Street, a 25-story office tower in Manhattan, was originally constructed in 2001. The building was acquired by Columbia Property Trust in 2007 and had been fully occupied by a single tenant until 2016. Following the tenant's departure, Columbia secured a 30-year lease with NYU Langone Medical Center. NYU Langone converted the building into a multispecialty ambulatory care facility, which began accepting patients in 2018. The property was later sold to Commerz Real for $332.5 million.

222 E 41st St, Manhattan, NYC is home to several NYU Langone facilities, including NYU Langone Urology Associates and NYU Langone Radiology—Ambulatory Care Center East 41st Street. The NYU Langone Ambulatory Care Center East 41st Street offers a range of outpatient services across various medical specialties.


222 East 41st Street is a 25-story Class A office building located in the Grand Central neighborhood of Manhattan. The building features a renovated lobby, common areas, and an onsite parking garage.


222 E 41st St, Manhattan, NYC, is a prominent office building with a notable tenant history. The building, a 25-story Class-A office tower, was leased in its entirety to NYU Langone Medical Center in 2016. NYU Langone converted the space into medical offices, ambulatory care facilities, and other ancillary uses.


Internet Providers at 222 E 41st St, Manhattan, NYC

  • Verizon Fios: Known for high speeds up to 2.3 Gbps and reliable service.
  • Spectrum: Offers speeds up to 1 Gbps with widespread coverage.
  • Astound Broadband Powered by RCN: Provides cable and fiber services with competitive pricing.
  • Earthlink: Offers fiber service with speeds up to 2,300 Mbps.

222 E 41st St, Manhattan, NYC is conveniently located near several transportation options.

Nearest Subway Stations: The closest subway stations are Grand Central-42 St (served by the 4, 5, 6, 7, S trains) and 42nd Street – Bryant Park (served by the B, D, F, M trains), both within a short walking distance.

Bus Stops: Nearby bus stops include E 41 St/1 Av and E 42 St/1 Av, served by buses M15, M15-SBS, M42, QM32, and QM34.

Train Stations: Grand Central Terminal is the nearest major train station, offering access to Metro-North Railroad and other services.

Cross Streets: The building is situated between 2nd Avenue and 3rd Avenue.

Office Tenants Rented / Leased 222 East 41st Street
  • NYU Langone Medical leased 390,000 SF
  • Jones Day leased 11,972 SF
  • Icon Parking Systems leased 1,000 SF
  • NYU Langone Medical Cen… leased 385,015 SF
  • Lavra, Paul, Christian leased 0 SF
  • NYU Langone Neurology… leased 0 SF
Nearby Office Tenants Leased
  • The United Nations leased 120,000 SF at 730 Third Ave
  • Convene leased 116,000 SF at 530 Fifth Avenue
  • WeWork leased 115,000 SF at 149 Madison Avenue
  • McLaughlin & Stern leased 112,000 SF at 260 Madison Avenue
  • TBWA Worldwide leased 107,308 SF at 488 Madison Ave
  • KPMG LLP leased 102,979 SF at 560 Lexington Ave
  • Bonnier Corp. leased 100,750 SF at 2 Park Ave
  • Crain Communications leased 100,000 SF at 711 Third Ave
  • Pernod Ricard USA, Inc. leased 97,444 SF at 250 Park Ave
  • W. W. Norton & Company leased 95,000 SF at 500 Fifth Avenue
Nearby Retail Tenants Leased
  • Le Pain Quotidien leased 6,050 SF at 3 Park Ave
  • Brooks Brothers leased 6,000 SF at 11 East 44th St
  • National Basketball Association leased 6,000 SF at 590 Fifth Ave
  • Designer Bargain Store leased 5,800 SF at 417 Fifth Ave
  • Fine & Rare leased 5,702 SF at 9 East 37th Street
  • Lex Dees Stores Inc. leased 5,372 SF at 420 Lexington Ave
  • Sephora leased 5,316 SF at 300 Madison Avenue
  • Wells Fargo leased 4,700 SF at 535 Madison Avenue
  • Joseph Abboud leased 4,600 SF at 424 Madison Ave
  • Daum Inc.; Haviland Inc. leased 4,500 SF at 499 Park Ave

VSA Consulting Group Testimonial

VSA Consulting Group testimonial To whom it may concern: I am writing to recommend Stephen Sunderland and Optimal Spaces Inc. for the excellent job they did in finding us a lease at our new space. They were fast and effecient in locating spaces that met our needs and corporate image, aggressive in negotiating on our behalf, and effective in communicating our needs to the landlord and getting our offer accepted. I look forward to working with the team at Optimal Spaces Inc. again. Very truly yours, Jack Sichterman Partner/Managing Director
Find My Space!