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Rent/Lease Office 380 Second Ave

$ / SF SF Monthly Rent

Nearby Sublease office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 59
10,500
$ 51,625
Park Ave S & Between East 19th Street $ 60
7,700
$ 38,500
Fifth Ave & East 19th Street $ 77
8,800
$ 56,466
Fifth Ave & East 16th Street $ 42
10,100
$ 35,350
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Type of Space Class A/month Class B/month Class C/month
Windowed office/person $ 2100 $ 2074 $ 775
Interior office/person $ 1350 $ 1574 $ 525
Team Rooms $ 10100 $ 8824 $ 5025
Suites $ 20100 $ 12824 $ 7025

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 92
9,100
$ 69,766
Park Ave S & East 20th Street $ 80
13,000
$ 87,208
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street $ 95
4,000
$ 31,666
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 60
8,300
$ 41,845
E 23rd St & Park Avenue $ 41
18,400
$ 62,866
Broadway & East 20th Street $ 70
18,200
$ 106,166
Park Ave S & Between East 19th Street $ 66
7,700
$ 42,670
Park Ave S & East 27th Street $ 75
8,700
$ 54,375
Fifth Ave & East 29th Street $ 78
12,500
$ 81,770
Park Ave S & East 27th Street $ 90
23,800
$ 178,500
Park Ave S & East 27th Street $ 69
13,100
$ 75,325
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Park Ave S & East 26th Street $ 48
12,000
$ 48,000
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 76
5,300
$ 33,787
E 23rd St & Park Avenue $ 42
6,100
$ 21,350
Broadway & East 20th Street $ 76
3,700
$ 23,433
Fifth Ave & East 29th Street $ 73
4,700
$ 28,591
Park Ave S & East 26th Street $ 70
3,900
$ 22,912
Park Ave S & East 26th Street $ 75
2,700
$ 16,875
University Pl & East 12th Street $ 50
6,500
$ 27,083
Broadway & East 18th Street $ 72
2,500
$ 15,104
Union Sq W & East 16th Street $ 66
3,700
$ 20,504
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 75
2,200
$ 13,750
E 23rd St & Third Avenue $ 46
2,400
$ 9,100
Park Ave S & East 26th Street $ 63
2,100
$ 11,025
Fifth Ave & East 29th Street $ 72
2,000
$ 12,016
Broadway & East 18th Street $ 74
1,800
$ 11,025
Address $ / SF SF Monthly Rent
E 19th St & Broadway $ 52
7,700
$ 33,687
Madison Ave & East 30th Street $ 39
11,000
$ 35,750
E 23rd St & Lexington Avenue $ 67
21,600
$ 120,600
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway $ 54
5,500
$ 24,979
Fifth Ave & East 29th Street $ 59
2,500
$ 12,291
Fifth Ave & Between East 28th Street $ 52
5,000
$ 21,875
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 38
2,300
$ 7,379
Broadway & East 21st Street $ 74
1,800
$ 11,175

Retail Spaces for Rent at 380 Second Ave

Rent Medical Space at 380 Second Ave

Office Tenants Rented / Leased 380 Second Avenue
  • NYU Hospitals Center leased 3,298 SF
  • New York Eye and Ear Infirmary leased 18,000 SF
  • Gramercy Surgery Center leased 10,000 SF
  • Metro Sports Medicine leased 2,500 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Niche leased 5,938 SF
  • NYU Langone Radiology leased 4,110 SF
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF
Nearby Office Tenants Leased
  • LivingSocial leased 60,405 SF at 101 Fifth Ave
  • Gerling America Insurance Co. leased 14,853 SF at 100 Park Ave
  • RDA International leased 14,000 SF at 100 Vandam St
  • Postworks New York leased 11,000 SF at 100 Avenue of the Americas
  • Digital Color Technologies leased 10,000 SF at 1001 Avenue of the Americas
  • Hunter Roberts Interiors leased 10,000 SF at 102 Madison Ave
  • Wedding Atelier leased 3,100 SF at 103 Fifth Ave
  • Audio Help Hearing Centers leased 1,500 SF at 1036 Park Ave
  • Jared Finkell, MD leased 500 SF at 10 Downing St
  • Century Pharmacy leased 500 SF at 10 Rutgers St
Nearby Retail Tenants Leased
  • Daffy's leased 18,000 SF at 111 Fifth Ave
  • Polo Ralph Lauren leased 11,000 SF at 1055 Madison Ave
  • New York Kids Club leased 4,000 SF at 11 Fifth Avenue
  • 10 Downing leased 3,400 SF at 10 Downing St
  • Clean Table leased 2,000 SF at 101 Seventh Avenue
  • Litter & Leashes leased 1,852 SF at 1100 Second Ave
  • 40/40 Club leased 1,200 SF at 1115 Broadway
  • Choza Taqueria leased 1,000 SF at 100 Park Ave
  • Simit and Smith leased 400 SF at 11 Waverly Pl
  • Sundaram Tagore Gallery leased 400 SF at 1100 Madison Ave
Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 380 Second Avenue. This trend is projected to continue. Opportunities for subleases remain available at 380 Second Avenue and in the nearby Gramercy Park neighborhood.
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380 Second Avenue Property Overview

Building Address: 380 Second Ave, New York NY 10010
Building Alternate Address: 380 2nd Ave
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:10
Year Built:1909
Building Class:B
Block & lot:00927-0055

The Gramercy Medical Arts Building, located at 380 Second Avenue in Manhattan, NYC, has a rich history dating back to the early 20th century. Constructed in 1909, it is situated in the Gramercy Park neighborhood and stands as a significant example of the area's development and transformation over time.

Originally built as a general office building, it has undergone transformations to become a hub for medical and educational institutions. The building was recently rebranded as the Gramercy Medical Arts Building due to its prominent tenants in the healthcare, arts, and education sectors.

It features a total of 182,258 square feet, spread across 10 stories. The building includes notable facilities such as bio-tech/lab spaces and offers amenities like 24-hour access, security systems, and Wi-Fi.

Current tenants include renowned institutions like NYU Langone Health, the Hospital for Joint Diseases, New York University, and the School of Visual Arts, reflecting its strategic importance in "Medical/Education Alley."

380 Second Avenue, Manhattan, NYC is also known as the Gramercy Medical Arts Building. Located in the heart of "Medical/Education Alley," it serves as a hub for renowned medical and educational institutions. The building stands 10 stories tall, offering 198,000 square feet of Class B office space with 20,000 rentable square foot floor plates. It features amenities like 24-hour access, biotech/lab space, concierge service, on-site management, security, high ceilings, and tenant-controlled HVAC. The property includes two handicapped-accessible lobbies and a private loading dock on 22nd Street, making it ideal for healthcare-related businesses and medical practitioners. Notable tenants include NYU Langone Health, NYU's Department of Physical Therapy, Mt. Sinai's New York Eye & Ear Infirmary, and the School of Visual Arts.


Building Amenities at 380 Second Avenue, Manhattan, NYC

  • 24-hour access
  • Biotech/lab space
  • Concierge service
  • On-site property management and security
  • High ceilings
  • Tenant-controlled HVAC
  • 300-pound floor loads
  • Two handicapped-accessible lobbies
  • Private loading dock on 22nd Street
  • Medical office features including hardwood floors, good natural light, and north and west views along 2nd Avenue
  • Existing buildout with reception area, consultation room, exam rooms with sinks and built-in cabinetry, lab room, and private restroom
  • Long-term stable ownership with ongoing renovation and expansion of second lobby at 310 East 22nd Street

Office Tenants at 380 Second Avenue, Manhattan, NYC

380 Second Avenue is a prominent 10-story Class B office and medical building located in Manhattan’s Gramercy Park neighborhood. Known as the Gramercy Medical Arts Building, it hosts a prestigious roster of tenants primarily from healthcare, medical, and educational sectors.

  • Gramercy Surgery Center
  • NYU Langone Health
  • NYU’s Department of Physical Therapy and College of Dentistry
  • NYU Langone Hospital's Diagnostic Imaging Center
  • Hospital for Joint Diseases (NYU Langone)
  • Mt. Sinai’s New York Eye & Ear Infirmary
  • School of Visual Arts
  • MedRite
  • East Side Endoscopy
  • Gramercy Surgical Center

The building features amenities including tenant-controlled HVAC, 24-hour access, concierge service, on-site property management and security, high ceilings, biotech/lab space, and a private loading dock. The floors have a 300-pound load capacity and benefit from abundant natural light, with the upper floors offering views of the NYC skyline.


Internet Providers at 380 Second Ave, Manhattan, NYC:

Although specific providers at this location are not listed, typical internet providers in Manhattan include:

  • Verizon Fios: Known for high speeds and reliable fiber-optic service.
  • Astound Broadband Powered by RCN: Offers cable and fiber services with competitive pricing.
  • Spectrum: Provides widespread cable internet coverage across Manhattan.
  • Other Options: T-Mobile Home Internet and fixed wireless providers like STARRY may also be available.

For precise availability, contacting each provider directly is recommended.


380 Second Avenue is located in the heart of Manhattan's Gramercy Park neighborhood. It is easily accessible by public transportation.

Nearest Subway Stations: - 23rd Street (R, W trains) - 14th Street – Union Square (4, 5, 6, L, N, Q, W trains)

Bus Lines: - BM3, M101, M15-SBS, M23-SBS, M34A-SBS

Cross Streets: - First Avenue and Second Avenue

Public Transportation Directions: - To get there by subway, take the R or W train to 23rd Street and exit towards 2nd Avenue. - For bus, take any of the bus lines mentioned above and get off at the nearest stop to 2nd Avenue and 23rd Street.

Office Tenants Rented / Leased 380 Second Avenue
  • NYU Hospitals Center leased 3,298 SF
  • New York Eye and Ear Infirmary leased 18,000 SF
  • Gramercy Surgery Center leased 10,000 SF
  • Metro Sports Medicine leased 2,500 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Niche leased 5,938 SF
  • NYU Langone Radiology leased 4,110 SF
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF

Nearby Office Tenants Leased
  • LivingSocial leased 60,405 SF at 101 Fifth Ave
  • Gerling America Insurance Co. leased 14,853 SF at 100 Park Ave
  • RDA International leased 14,000 SF at 100 Vandam St
  • Postworks New York leased 11,000 SF at 100 Avenue of the Americas
  • Digital Color Technologies leased 10,000 SF at 1001 Avenue of the Americas
  • Hunter Roberts Interiors leased 10,000 SF at 102 Madison Ave
  • Wedding Atelier leased 3,100 SF at 103 Fifth Ave
  • Audio Help Hearing Centers leased 1,500 SF at 1036 Park Ave
  • Jared Finkell, MD leased 500 SF at 10 Downing St
  • Century Pharmacy leased 500 SF at 10 Rutgers St

Nearby Retail Tenants Leased
  • Daffy's leased 18,000 SF at 111 Fifth Ave
  • Polo Ralph Lauren leased 11,000 SF at 1055 Madison Ave
  • New York Kids Club leased 4,000 SF at 11 Fifth Avenue
  • 10 Downing leased 3,400 SF at 10 Downing St
  • Clean Table leased 2,000 SF at 101 Seventh Avenue
  • Litter & Leashes leased 1,852 SF at 1100 Second Ave
  • 40/40 Club leased 1,200 SF at 1115 Broadway
  • Choza Taqueria leased 1,000 SF at 100 Park Ave
  • Simit and Smith leased 400 SF at 11 Waverly Pl
  • Sundaram Tagore Gallery leased 400 SF at 1100 Madison Ave
Office Tenants Rented / Leased 380 Second Avenue
  • NYU Hospitals Center leased 3,298 SF
  • New York Eye and Ear Infirmary leased 18,000 SF
  • Gramercy Surgery Center leased 10,000 SF
  • Metro Sports Medicine leased 2,500 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Niche leased 5,938 SF
  • NYU Langone Radiology leased 4,110 SF
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF
Nearby Office Tenants Leased
  • LivingSocial leased 60,405 SF at 101 Fifth Ave
  • Gerling America Insurance Co. leased 14,853 SF at 100 Park Ave
  • RDA International leased 14,000 SF at 100 Vandam St
  • Postworks New York leased 11,000 SF at 100 Avenue of the Americas
  • Digital Color Technologies leased 10,000 SF at 1001 Avenue of the Americas
  • Hunter Roberts Interiors leased 10,000 SF at 102 Madison Ave
  • Wedding Atelier leased 3,100 SF at 103 Fifth Ave
  • Audio Help Hearing Centers leased 1,500 SF at 1036 Park Ave
  • Jared Finkell, MD leased 500 SF at 10 Downing St
  • Century Pharmacy leased 500 SF at 10 Rutgers St
Nearby Retail Tenants Leased
  • Daffy's leased 18,000 SF at 111 Fifth Ave
  • Polo Ralph Lauren leased 11,000 SF at 1055 Madison Ave
  • New York Kids Club leased 4,000 SF at 11 Fifth Avenue
  • 10 Downing leased 3,400 SF at 10 Downing St
  • Clean Table leased 2,000 SF at 101 Seventh Avenue
  • Litter & Leashes leased 1,852 SF at 1100 Second Ave
  • 40/40 Club leased 1,200 SF at 1115 Broadway
  • Choza Taqueria leased 1,000 SF at 100 Park Ave
  • Simit and Smith leased 400 SF at 11 Waverly Pl
  • Sundaram Tagore Gallery leased 400 SF at 1100 Madison Ave

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Alone or with other broker

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Why Use a Tenant Broker: Your Advocate in Commercial Real Estate
1. The Crucial Distinction: Whose Side Are They On?
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Summary: Don’t rely on the landlord’s agent. A tenant broker is your advocate, provides better data, negotiates a complete package, and typically costs you nothing.

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