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Rent/Lease Office 380 Second Ave

Nearby Sublease office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 59
10,500
$ 51,625
Park Ave S & Between East 19th Street $ 60
7,700
$ 38,500
Fifth Ave & East 21st Street $ 69
7,300
$ 41,975
Fifth Ave & East 19th Street $ 77
8,800
$ 56,466
Fifth Ave & East 16th Street $ 42
10,100
$ 35,350
Address $ / SF SF Monthly Rent
Fifth Ave & East 21st Street $ 71
5,200
$ 30,766
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
E 16th St & Park Avenue South $ 64
3,400
$ 18,275
Address $ / SF SF Monthly Rent
Type of Space Class A/month Class B/month Class C/month
Windowed office/person
Interior office/person
Team Rooms
Suites

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 92
9,100
$ 69,766
Park Ave S & East 20th Street $ 81
13,000
$ 87,750
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street $ 95
4,000
$ 31,666
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 61
8,300
$ 42,191
E 23rd St & Park Avenue $ 42
18,400
$ 64,400
Broadway & East 20th Street $ 70
18,200
$ 106,925
Park Ave S & Between East 19th Street $ 67
7,700
$ 42,991
Park Ave S & East 27th Street $ 75
8,700
$ 54,375
Fifth Ave & East 29th Street $ 79
12,500
$ 82,291
Park Ave S & East 27th Street $ 91
23,800
$ 180,483
Park Ave S & East 27th Street $ 70
13,100
$ 75,870
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Park Ave S & East 26th Street $ 48
12,000
$ 48,500
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 76
5,300
$ 33,787
E 23rd St & Park Avenue $ 41
6,100
$ 20,841
Broadway & East 20th Street $ 75
3,700
$ 23,125
Fifth Ave & East 29th Street $ 72
4,700
$ 28,200
Park Ave S & East 26th Street $ 71
3,900
$ 23,075
Park Ave S & East 26th Street $ 75
2,700
$ 16,875
University Pl & East 12th Street $ 49
6,500
$ 26,541
Broadway & East 18th Street $ 72
2,500
$ 14,895
Union Sq W & East 16th Street $ 67
3,700
$ 20,658
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 75
2,200
$ 13,750
E 23rd St & Third Avenue $ 46
2,400
$ 9,100
Park Ave S & East 26th Street $ 63
2,100
$ 11,025
Fifth Ave & East 29th Street $ 73
2,000
$ 12,100
Broadway & East 18th Street $ 74
1,800
$ 11,025
Address $ / SF SF Monthly Rent
E 19th St & Broadway $ 52
7,700
$ 33,687
Madison Ave & East 30th Street $ 40
11,000
$ 36,208
E 23rd St & Lexington Avenue $ 68
21,600
$ 121,500
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway $ 54
5,500
$ 24,520
Fifth Ave & East 29th Street $ 58
2,500
$ 12,083
Fifth Ave & Between East 28th Street $ 52
5,000
$ 21,458
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 38
2,300
$ 7,379
Broadway & East 21st Street $ 74
1,800
$ 11,175

Retail Spaces for Rent at 380 Second Ave

Rent Retail 380 Second Ave

Rent Medical Space at 380 Second Ave

Office Tenants Rented / Leased 380 Second Avenue
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Pain Management NYC leased 2,255 SF
  • Niche leased 5,938 SF
  • Hanger Prosthetics & Orthotics leased 1,334 SF
  • Meridian Imaging Group leased 5,341 SF
  • The School of Visual Arts leased 80,000 SF
  • NYU Hospitals Center leased 3,298 SF
Nearby Office Tenants Leased
  • Laser & Skin Surgery Cen… leased 33,381 SF at 317 East 34th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Shinhan Bank America leased 32,250 SF at 475 Park Avenue South
  • Numerix leased 31,615 SF at 99 Park Ave
  • Operative Media leased 30,720 SF at 6 East 32nd St
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S
  • WeWork leased 28,500 SF at 185 Madison Avenue
  • WH Freeman and Worth Publishers leased 28,000 SF at 41 Madison Ave
  • IBM leased 27,699 SF at 19 Union Square West
Nearby Retail Tenants Leased
  • Bonobos Guideshop leased 4,000 SF at 95 Fifth Ave
  • Mexican Hospitality Operator LLC leased 3,700 SF at 35 East 21st St
  • Wireless Generation leased 3,613 SF at 11 East 26th St
  • Brideside Bride leased 3,500 SF at 20 East 20th Street
  • Damien Scoditti leased 3,500 SF at 920 Broadway
  • Exki leased 3,000 SF at 76 Madison Ave
  • Maison Kayser leased 3,000 SF at 841 Broadway
  • Fresh & Co. leased 3,000 SF at 425 Park Ave South
  • Wahoo's Fish Taco leased 2,800 SF at 333 Park Ave South
  • Hale & Hearty Soups leased 2,800 SF at 432 Park Ave South
$ / SF SF Monthly Rent
Please notify me when a new space is available
Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 380 Second Avenue. This trend is projected to continue. Opportunities for subleases remain available at 380 Second Avenue and in the nearby Gramercy Park neighborhood.
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380 Second Avenue Property Overview

Building Address: 380 Second Ave, New York NY 10010
Building Alternate Address: 380 2nd Ave
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:10
Year Built:1909
Building Class:B
Block & lot:00927-0055

The Gramercy Medical Arts Building, located at 380 Second Avenue in Manhattan, NYC, has a rich history dating back to the early 20th century. Constructed in 1909, it is situated in the Gramercy Park neighborhood and stands as a significant example of the area's development and transformation over time.

Originally built as a general office building, it has undergone transformations to become a hub for medical and educational institutions. The building was recently rebranded as the Gramercy Medical Arts Building due to its prominent tenants in the healthcare, arts, and education sectors.

It features a total of 182,258 square feet, spread across 10 stories. The building includes notable facilities such as bio-tech/lab spaces and offers amenities like 24-hour access, security systems, and Wi-Fi.

Current tenants include renowned institutions like NYU Langone Health, the Hospital for Joint Diseases, New York University, and the School of Visual Arts, reflecting its strategic importance in "Medical/Education Alley."

380 Second Avenue, Manhattan, NYC is also known as the Gramercy Medical Arts Building. Located in the heart of "Medical/Education Alley," it serves as a hub for renowned medical and educational institutions. The building stands 10 stories tall, offering 198,000 square feet of Class B office space with 20,000 rentable square foot floor plates. It features amenities like 24-hour access, biotech/lab space, concierge service, on-site management, security, high ceilings, and tenant-controlled HVAC. The property includes two handicapped-accessible lobbies and a private loading dock on 22nd Street, making it ideal for healthcare-related businesses and medical practitioners. Notable tenants include NYU Langone Health, NYU's Department of Physical Therapy, Mt. Sinai's New York Eye & Ear Infirmary, and the School of Visual Arts.


Building Amenities at 380 Second Avenue, Manhattan, NYC

  • 24-hour access
  • Biotech/lab space
  • Concierge service
  • On-site property management and security
  • High ceilings
  • Tenant-controlled HVAC
  • 300-pound floor loads
  • Two handicapped-accessible lobbies
  • Private loading dock on 22nd Street
  • Medical office features including hardwood floors, good natural light, and north and west views along 2nd Avenue
  • Existing buildout with reception area, consultation room, exam rooms with sinks and built-in cabinetry, lab room, and private restroom
  • Long-term stable ownership with ongoing renovation and expansion of second lobby at 310 East 22nd Street

Office Tenants at 380 Second Avenue, Manhattan, NYC

380 Second Avenue is a prominent 10-story Class B office and medical building located in Manhattan’s Gramercy Park neighborhood. Known as the Gramercy Medical Arts Building, it hosts a prestigious roster of tenants primarily from healthcare, medical, and educational sectors.

  • Gramercy Surgery Center
  • NYU Langone Health
  • NYU’s Department of Physical Therapy and College of Dentistry
  • NYU Langone Hospital's Diagnostic Imaging Center
  • Hospital for Joint Diseases (NYU Langone)
  • Mt. Sinai’s New York Eye & Ear Infirmary
  • School of Visual Arts
  • MedRite
  • East Side Endoscopy
  • Gramercy Surgical Center

The building features amenities including tenant-controlled HVAC, 24-hour access, concierge service, on-site property management and security, high ceilings, biotech/lab space, and a private loading dock. The floors have a 300-pound load capacity and benefit from abundant natural light, with the upper floors offering views of the NYC skyline.


Internet Providers at 380 Second Ave, Manhattan, NYC:

Although specific providers at this location are not listed, typical internet providers in Manhattan include:

  • Verizon Fios: Known for high speeds and reliable fiber-optic service.
  • Astound Broadband Powered by RCN: Offers cable and fiber services with competitive pricing.
  • Spectrum: Provides widespread cable internet coverage across Manhattan.
  • Other Options: T-Mobile Home Internet and fixed wireless providers like STARRY may also be available.

For precise availability, contacting each provider directly is recommended.


380 Second Avenue is located in the heart of Manhattan's Gramercy Park neighborhood. It is easily accessible by public transportation.

Nearest Subway Stations: - 23rd Street (R, W trains) - 14th Street – Union Square (4, 5, 6, L, N, Q, W trains)

Bus Lines: - BM3, M101, M15-SBS, M23-SBS, M34A-SBS

Cross Streets: - First Avenue and Second Avenue

Public Transportation Directions: - To get there by subway, take the R or W train to 23rd Street and exit towards 2nd Avenue. - For bus, take any of the bus lines mentioned above and get off at the nearest stop to 2nd Avenue and 23rd Street.

Office Tenants Rented / Leased 380 Second Avenue
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Pain Management NYC leased 2,255 SF
  • Niche leased 5,938 SF
  • Hanger Prosthetics & Orthotics leased 1,334 SF
  • Meridian Imaging Group leased 5,341 SF
  • The School of Visual Arts leased 80,000 SF
  • NYU Hospitals Center leased 3,298 SF

Nearby Office Tenants Leased
  • Laser & Skin Surgery Cen… leased 33,381 SF at 317 East 34th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Shinhan Bank America leased 32,250 SF at 475 Park Avenue South
  • Numerix leased 31,615 SF at 99 Park Ave
  • Operative Media leased 30,720 SF at 6 East 32nd St
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S
  • WeWork leased 28,500 SF at 185 Madison Avenue
  • WH Freeman and Worth Publishers leased 28,000 SF at 41 Madison Ave
  • IBM leased 27,699 SF at 19 Union Square West

Nearby Retail Tenants Leased
  • Bonobos Guideshop leased 4,000 SF at 95 Fifth Ave
  • Mexican Hospitality Operator LLC leased 3,700 SF at 35 East 21st St
  • Wireless Generation leased 3,613 SF at 11 East 26th St
  • Brideside Bride leased 3,500 SF at 20 East 20th Street
  • Damien Scoditti leased 3,500 SF at 920 Broadway
  • Exki leased 3,000 SF at 76 Madison Ave
  • Maison Kayser leased 3,000 SF at 841 Broadway
  • Fresh & Co. leased 3,000 SF at 425 Park Ave South
  • Wahoo's Fish Taco leased 2,800 SF at 333 Park Ave South
  • Hale & Hearty Soups leased 2,800 SF at 432 Park Ave South
Office Tenants Rented / Leased 380 Second Avenue
  • Eastside Endoscopy leased 12,000 SF
  • NYU Steinhardt leased 18,000 SF
  • New York Eye & Ear Infir… leased 18,000 SF
  • 380 Second, LLC leased 1,000 SF
  • Pain Management NYC leased 2,255 SF
  • Niche leased 5,938 SF
  • Hanger Prosthetics & Orthotics leased 1,334 SF
  • Meridian Imaging Group leased 5,341 SF
  • The School of Visual Arts leased 80,000 SF
  • NYU Hospitals Center leased 3,298 SF
Nearby Office Tenants Leased
  • Laser & Skin Surgery Cen… leased 33,381 SF at 317 East 34th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Shinhan Bank America leased 32,250 SF at 475 Park Avenue South
  • Numerix leased 31,615 SF at 99 Park Ave
  • Operative Media leased 30,720 SF at 6 East 32nd St
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S
  • WeWork leased 28,500 SF at 185 Madison Avenue
  • WH Freeman and Worth Publishers leased 28,000 SF at 41 Madison Ave
  • IBM leased 27,699 SF at 19 Union Square West
Nearby Retail Tenants Leased
  • Bonobos Guideshop leased 4,000 SF at 95 Fifth Ave
  • Mexican Hospitality Operator LLC leased 3,700 SF at 35 East 21st St
  • Wireless Generation leased 3,613 SF at 11 East 26th St
  • Brideside Bride leased 3,500 SF at 20 East 20th Street
  • Damien Scoditti leased 3,500 SF at 920 Broadway
  • Exki leased 3,000 SF at 76 Madison Ave
  • Maison Kayser leased 3,000 SF at 841 Broadway
  • Fresh & Co. leased 3,000 SF at 425 Park Ave South
  • Wahoo's Fish Taco leased 2,800 SF at 333 Park Ave South
  • Hale & Hearty Soups leased 2,800 SF at 432 Park Ave South

C2 Media Testimonial

C2 Media testimonial To Whom It May Concern: I would like to highly commend Robert King for his professional assistance in helping me locate a new corporate office. Locating the right space takes time, and I was impressed with Robert’s patience not only with myself but with my overseas executives. He never tired of our endless meetings and requests. We found a space we love. And in spite of us concluding our deal, Robert every so often comes by to chat and make sure all is going well professionably and personally. I enthusiastically recommend Robert and Optimal Spaces to anyone looking for space in New York City. Sincerely, Evelyn Pabon Product and Sales Manager C2 Inc. - Contempo Group
🤝
Tenant Representation: Optimal Spaces acts exclusively as a "Tenant Broker," only representing tenants, never landlords.
⚖️
Unbiased Service: Avoiding conflicts of interest, they provide impartial service, showing a wider range of properties and negotiating the best price.
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Comprehensive Process: Agents guide clients end-to-end, offering market surveys, floor plans, pricing expectations, and industry contacts.
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Cost Savings: They negotiate rental price and identify/abate "hidden costs."

Why Optimal Spaces –
Tenant Broker

✓
  • No fee for clients renting space.
  • We work for YOU, not the landlord.
  • Save 15–20% on your business costs.
  • Save 100–200 hours of research.
  • Access to all available spaces.
  • Specialized real estate expertise.

Alone or with other broker

✕
  • Miss deals and hard-to-find spaces.
  • Potential conflict of interest (often represent landlords).
  • Only 10% of available spaces are online.
  • Lack of specialized expertise.
  • May not get the best terms or uncover hidden costs.
Why Use a Tenant Broker: Your Advocate in Commercial Real Estate
1. The Crucial Distinction: Whose Side Are They On?
2. It Almost Always Costs You Nothing
3. Access to “Hidden” Inventory
4. Negotiating Beyond Base Rent
5. Time Savings & Process Management
6. Mitigating Risk (the “Gotchas”)
Summary: Don’t rely on the landlord’s agent. A tenant broker is your advocate, provides better data, negotiates a complete package, and typically costs you nothing.
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Optimal Spaces negotiates tenant deals, typically securing 15-20% savings. We find the perfect commercial space in New York, offering a wide range of options: office, educational, industrial, retail, medical, and loft spaces.
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