Harlem Office Space for Rent
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Harlem Office Space Listings
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Offices for Rent | ||||
| C | E 124th Street & Park Avenue Floor 5 (full) | 12,500 | $ Negotiable | |
| B | W 125th Street & Malcolm X Blvd Floor 13 (full) | 12,000 | $ 53,000 | |
| C | E 124th Street & Park Avenue Floor 5 (full) | 11,600 | $ 45,400 | |
| A | W 126th Street & Amsterdam Avenue Floor 11 (full) | 11,000 | $ Negotiable | |
| B | W 125th Street & Lenox Avenue Floor 6 (full) | 10,000 | $ Negotiable | |
| A | W 126th Street & Amsterdam Avenue Floor 11 (full) | 9,500 | $ Negotiable | |
| C | E 106th Street & Third Avenue Floor 1 (full) | 8,900 | $ Negotiable | |
| B | 7,400 | $ 28,800 | ||
| Medium Offices for Rent | ||||
| B | 5,300 | $ Negotiable | ||
| C | E 106th Street & Third Avenue Floor 2 (full) | 3,700 | $ Negotiable | |
| C | Park Ave & East 130th Street Floor 2 | 3,600 | $ Negotiable | |
| B | Park Ave & East 125th Street Floor 2 | 3,400 | $ 13,600 | |
| B | W 125th Street & Malcolm X Blvd Floor 11 | 2,800 | $ 12,600 | |
| Small Offices for Rent | ||||
| B | 2,400 | $ Negotiable | ||
| C | 2,200 | $ Negotiable | ||
| C | Park Ave & East 130th Street Floor 6 | 1,900 | $ Negotiable | |
| B | 1,800 | $ Negotiable | ||
| C | Riverside Dr & West 119th Street Floor 19 | 1,800 | $ 4,000 | |
| C | Park Ave & East 130th Street Floor 2 | 1,600 | $ 3,400 | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Medium Offices for Rent | ||||
| B | Lenox Ave & West 124th Street Floor 3 (full) | 4,500 | $ Negotiable | |
| B | Lenox Ave & West 124th Street Floor 4 (full) | 4,500 | $ Negotiable | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Offices for Rent | ||||
| A | Madison Ave & East 51st Street Plaza District · Floor 12 | 7,300 | $ Negotiable | |
| A | Madison Ave & East 40th Street Grand Central · Floor 17 (full) | 7,200 | $ 43,400 | |
| B | Fifth Ave & East 37th Street Murray Hill · Floor 8 | 7,200 | $ 30,200 | |
| B | Madison Ave & East 46th Street Grand Central · Floor 14 (full) | 7,200 | $ Negotiable | |
| B | Madison Ave & East 46th Street Grand Central · Floor 10 (full) | 7,200 | $ 47,400 | |
| A | E 42nd Street & Second Avenue Grand Central · Floor 23 (full) | 7,100 | $ Negotiable | |
| Medium Offices for Rent | ||||
| A | Third Ave & East 58th Street Plaza District · Floor 3 | 2,600 | $ Negotiable | |
| A | Lexington Ave & East 59th Street Plaza District · Floor 15 | 2,500 | $ Negotiable | |
| B | E 61st Street & Second Avenue Plaza District · Floor 6 | 2,500 | $ 12,600 | |
| B | Madison Ave & East 40th Street Grand Central · Floor 45 (full) | 2,500 | $ 14,200 | |
| Small Offices for Rent | ||||
| B | W 57th Street & Avenue of the Americas Plaza District · Floor 9 | 1,600 | $ 9,200 | |
| A | Third Ave & East 58th Street Plaza District · Floor 18 | 1,600 | $ Negotiable | |
| C | E 40th Street & Lexington Avenue Grand Central · Floor 3 | 1,600 | $ Negotiable | |
| A | Third Ave & East 58th Street Plaza District · Floor 18 | 1,600 | $ Negotiable | |
| B | W 57th Street & Avenue of the Americas Columbus Circle · Floor 4 | 1,500 | $ 7,600 | |
Office Tenants Rented / Leased Harlem
- Volastra Therapeutics leased 11,000 SF at 1361 Amsterdam Avenue
- United States Census Bureau leased 10,000 SF at 1361 Amsterdam Avenue
- M & T Bank leased 1,500 SF at 310 Lenox Avenue
- Grant Associates leased 7,000 SF at 1825 Park Avenue
- NADAP Inc. leased 9,276 SF at 1825 Park Avenue
- YAI Network leased 8,449 SF at 310 Lenox Ave
- National Black Leadership Commission on AIDS leased 3,005 SF at 215 West 125th St
- EmblemHealth Company HIP Health Plan of New York leased 32,114 SF at 215 West 125th St
- William J. Clinton Foundation leased 8,715 SF at 55 West 125th St
- New York State Workers' Compensation Board leased 45,205 SF at 215 West 125th St
- New York State Department of Labor leased 26,546 SF at 215 West 125th St
- Veritas Therapeutic Community Inc. leased 12,285 SF at 55 West 125th St
- Success Charter Network leased 8,449 SF at 310 Lenox Ave
- Learn-It Systems leased 1,398 SF at 1825 Park Ave
Why Optimal Spaces –
Tenant Broker
- No fee for clients renting space.
- We work for YOU, not the landlord.
- Save 10–15% on your business costs.
- Save 100–200 hours of research.
- Access to all available spaces.
- Specialized real estate expertise.
Alone or with other broker
- Miss deals and hard-to-find spaces.
- Potential conflict of interest (often represent landlords).
- Only 10% of available spaces are online.
- Lack of specialized expertise.
- May not get the best terms or uncover hidden costs.
1. The Crucial Distinction: Whose Side Are They On?
2. It Almost Always Costs You Nothing
3. Access to “Hidden” Inventory
4. Negotiating Beyond Base Rent
5. Time Savings & Process Management
6. Mitigating Risk (the “Gotchas”)
About Harlem
Geographic Boundaries
Harlem is a neighborhood in Upper Manhattan, New York City, with fluid boundaries generally defined by 155th Street to the north, the Harlem and East Rivers to the east, and Central Park North (110th Street) to the south. The western edge borders the Hudson River, though some definitions extend to Amsterdam Avenue. East Harlem (El Barrio) lies northeast of Central Harlem, bounded by the East River, Harlem River, and 96th Street near Central Park. The greater Harlem area spans approximately 1.4 to 4.4 square miles depending on sub-neighborhood inclusions.
Businesses and Retail
Harlem's commercial landscape blends historic institutions with modern ventures. 125th Street serves as the main retail corridor, housing national retailers like H&M and Old Navy alongside local staples such as the Apollo Theater's gift shop. Specialty stores include Silk Road Cigars and Harlem Haberdashery (men's clothing). The neighborhood hosts multiple farmers' markets, including the Harlem Grown market on 134th Street. Fine dining establishments range from Red Rooster Harlem by Marcus Samuelsson to Sylvia's Restaurant, a soul food landmark since 1962.
Historical Attractions
Key cultural landmarks include the Apollo Theater (1914), which launched careers of Ella Fitzgerald and James Brown, and the Abyssinian Baptist Church (1808), a center of Black political activism. The Studio Museum in Harlem (1968) showcases African-American art, while the Schomburg Center for Research in Black Culture houses rare manuscripts like Malcolm X's diaries. Historic residential buildings like the Strivers' Row townhouses (1890s) exemplify late-19th-century row-house architecture.
Architectural Landscape
Building types range from pre-war brownstones and limestone row houses to public housing complexes like the General Grant Houses. Notable structures include the neo-Gothic Revival City College of New York campus and the modernist Adam Clayton Powell Jr. State Office Building. Recent developments like the Harlem Row complex on Frederick Douglass Boulevard blend retail and luxury residential spaces.
Transportation Infrastructure
Major subway lines include the A/B/C/D trains at 125th Street and the 2/3 trains along Lenox Avenue. Metro-North Railroad services Harlem-125th Street Station with connections to Westchester and Connecticut. The M60 Select Bus Service provides access to LaGuardia Airport, while multiple bike lanes connect to Manhattan's cycling grid. Key bus routes include the M101 and M7 along major avenues.
Zip Codes
Primary ZIP codes include 10026 (Central Harlem), 10027 (Morningside Heights overlap), 10030 and 10037 (Central Harlem), 10035 (East Harlem), and 10039 (Central Harlem). Adjacent areas use 10025 (Upper West Side) and 10029 (East Harlem overlap).
Corporate Presence
Columbia University's Manhattanville Campus expansion anchors academic and research enterprises. Major employers include Mount Sinai Hospital's satellite facilities and the Harlem Hospital Center. Tech incubators like the Harlem Biospace support life sciences startups. Retail chains such as Target and Whole Foods operate large-format stores in the area.
Office Buildings in Harlem
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