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Plaza District Medical Office Listings
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| A | E 57th Street & Park Avenue Floor 16 (full) | 9,700 | $ Negotiable | |
| B | E 48th Street & Madison Avenue Floor 3 (full) | 8,000 | $ Negotiable | |
| C | W 57th Street & Seventh Avenue Floor 10 | 5,300 | $ 29,000 | |
| Medium Medical Offices for Rent | ||||
| B | 4,100 | $ 20,000 | ||
| B | E 48th Street & Madison Avenue Floor 12 (full) | 3,800 | $ Negotiable | |
| B | E 55th Street & Park Avenue Floor 10 (full) | 3,500 | $ 26,200 | |
| B | 3,100 | $ Negotiable | ||
| C | 3,000 | $ Negotiable | ||
| Small Medical Offices for Rent | ||||
| C | 2,000 | $ 10,800 | ||
| B | E 60th Street & Madison Avenue Floor 17 | 1,900 | $ Negotiable | |
| B | E 56th Street & Park Avenue Floor 5 | 1,700 | $ 8,200 | |
| B | E 56th Street & Madison Avenue Floor 11 | 1,400 | $ 5,600 | |
| B | 1,100 | $ Negotiable | ||
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | E 56th Street & Madison Avenue Floor 2 (full) | 6,900 | $ 38,400 | |
| Small Medical Offices for Rent | ||||
| A | W 56th Street & Seventh Avenue Floor 10 | 2,000 | $ Negotiable | |
| A | E 57th Street & Park Avenue Floor 6 | 1,000 | $ Negotiable | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | W 34th Street & Avenue of the Americas Penn Plaza/Garment · Floor 6 (full) | 10,500 | $ Negotiable | |
| B | W 34th Street & Avenue of the Americas Penn Plaza/Garment · Floor 6 (full) | 9,500 | $ Negotiable | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 6,000 | $ 20,000 | |
| C | W 29th Street & Seventh Avenue Chelsea · Floor 12 | 6,000 | $ 15,000 | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 5,000 | $ 16,600 | |
| Medium Medical Offices for Rent | ||||
| B | W 44th Street & Fifth Avenue Times Square · Floor 10 | 3,600 | $ 10,800 | |
| C | E 47th Street & Second Avenue U.N. Plaza · Floor 9 | 3,500 | $ 16,200 | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 3,000 | $ 10,000 | |
| Small Medical Offices for Rent | ||||
| B | Park Ave & East 79th Street Upper East Side · Ground floor | 1,200 | $ Negotiable | |
| C | W 29th Street & Seventh Avenue Chelsea · Floor 12 | 1,200 | $ Negotiable | |
| B | W 48th Street & Avenue of the Americas Plaza District · Floor 11 | 1,100 | $ 5,800 | |
| B | Park Ave & East 79th Street Upper East Side · Ground floor | 1,000 | $ Negotiable | |
| B | Park Ave & East 36th Street Murray Hill · Floor 1 | 1,000 | $ 5,400 | |
Medical Tenants Rented / Leased Plaza District
- Omid Nikrouz, MD. PC. leased 2,152 SF at 133 E 58th St
- Dr. Joshua Levine, MD, PC leased 2,000 SF at 57 W 57th St
- 501 Restorative leased 1,750 SF at 501 Madison Ave
- NYC Periodontics & Implant Dentistry leased 1,750 SF at 501 Madison Ave
- Midtown East Medical leased 1,653 SF at 120 E 56th St
- JCG Weight Loss & Wellness leased 1,617 SF at 133 E 58th St
- Ronald D. Blatt M.D. leased 1,530 SF at 635 Madison Ave
- Jutkowitz Periodontics & Implantology leased 1,509 SF at 133 E 58th St
- Blooming Smiles Dental leased 1,500 SF at 501 Madison Ave
- Optimal Wellness leased 1,375 SF at 160 E 56th St
- Noah Heftler, MD leased 1,354 SF at 133 E 58th St
- Cosmetic Prosthodontics PLLC leased 1,078 SF at 133 E 58th St
- Madison Avenue Cardiovascular & Concierge Medicine leased 450 SF at 635 Madison Ave
- ITS Academy leased 265 SF at 635 Madison Ave
Excellent opportunities for medical space still exist if you know where to look. Optimal Spaces has a proven track record of securing these spaces for our clients on the best possible terms.
We are dedicated tenant brokers, meaning we exclusively represent your interests, never the landlord’s.
Why choose Optimal Spaces?
- Significant Savings: We typically save clients 10–15% compared with what they could negotiate on their own.
- Time Efficiency: We eliminate 100–200 hours of blind, unnecessary research for you.
- No Conflict of Interest: We represent only you, not the landlord.
Optimal Spaces consistently delivers exceptional spaces and advantageous deals for our clients. See their success: New York Medical Office Testimonials .
Why Optimal Spaces Tenant Broker
- Lease negotiation: full terms, renewals, expansion options
- Cost analysis, inventory identification, negotiating scope
- Risk mitigation against hidden pitfalls
Cost Savings
- Negotiate 30+ leasing points to prevent hidden costs
- Save 10–15% on total leasing costs
- Save 100–200 hours filtering unviable spaces
- Property access via broker databases and networks (off-market, subleases, future availability)
Alone or With Other Brokers
- Managing agents owe a fiduciary duty to landlords, seeking maximum price and terms rather than tenant savings.
- Inherent conflict of interest as most brokers represent landlords
- Risk of weaker terms and overlooked hidden costs
- Heavy workload falls on you while best spaces are missed
About Plaza District
Introduction to Plaza District, NYC
The Plaza District in Midtown Manhattan is a vibrant and prestigious neighborhood known for its luxury amenities, high-end businesses, and iconic landmarks. It is bounded by 59th Street to the north, 48th Street to the south, Third Avenue to the east, and Seventh Avenue to the west. This area is renowned for its expensive real estate, luxury shopping, and world-class dining options.Geographic Boundaries
Located in the heart of Manhattan, the Plaza District is strategically situated near major attractions like Times Square, the Metropolitan Museum of Art, MoMA, Carnegie Hall, and Radio City Music Hall. Its proximity to these iconic sites makes it a hub for both locals and tourists. The area offers stunning views of Central Park and is home to some of the most impressive skyscrapers in Manhattan.Businesses, Stores, Retailers, and Fine Restaurants
The Plaza District is a thriving commercial center hosting a variety of high-end businesses, including luxury retailers like Barneys and Bergdorf Goodman. The area is also home to numerous fine dining establishments that cater to diverse tastes, from upscale steakhouses to gourmet international cuisine. The presence of tech giants such as IBM, Apple, Accenture, and Microsoft adds to its prestige, attracting a diverse range of professionals and entrepreneurs.History of Major Attractions
One of the most iconic landmarks in the Plaza District is the Plaza Hotel, a symbol of luxury and elegance since its opening in 1907. The area has also been home to numerous cultural institutions, including Carnegie Hall, which has been a premier music venue since 1891. The Museum of Modern Art (MoMA), established in 1929, is another significant cultural attraction in the neighborhood.Types of Buildings and Significant Structures
The Plaza District features a mix of historic and modern architecture. The area is dominated by Class A office buildings, which are highly sought after by major corporations due to their prestige and prime location. The skyscrapers in this area offer breathtaking views of Central Park and are strategically located near major public transportation hubs. Significant buildings in the area include the iconic Plaza Hotel, the Solomon R. Guggenheim Museum, and the luxury residential buildings along Billionaires' Row, including One57 and 432 Park Avenue. These structures not only contribute to the area's architectural landscape but also reflect its status as a global epicenter of luxury and finance.Transportation Options
The Plaza District benefits from excellent public transportation options, with several subway lines passing through the area, including the B, D, F, and M trains at 59th Street – Columbus Circle and the 4, 5, 6, and 7 trains at Grand Central Terminal. Additionally, numerous bus routes serve the area, making it easily accessible by public transportation.Adjacent Zip Codes
The Plaza District is surrounded by several zip codes, including 10019, 10020, 10021, 10022, and 10065. These zip codes encompass a broader area of Midtown Manhattan, reflecting the neighborhood's central location.Prominent Companies and Businesses
The Plaza District is home to a variety of prominent companies across different sectors. Tech companies like IBM, Apple, Accenture, and Microsoft have offices in the area. Additionally, the neighborhood attracts high-profile tenants from the financial and legal sectors, including hedge funds and venture capital firms. The media and entertainment industries are also well-represented, given its proximity to major media outlets and entertainment venues. Overall, the Plaza District is a hub of economic and cultural activity, offering a unique blend of luxury, entertainment, and business opportunities that make it one of the most desirable locations in New York City.Office Buildings in Plaza District
- 630 Fifth Avenue
- 30 Rockefeller Plaza
- 1290 Avenue of the Americas
- 767 Fifth Avenue
- 345 Park Avenue
- 277 Park Avenue
- 399 Park Avenue
- 9 West 57th Street
- 660 Fifth Avenue
- 919 Third Avenue
- 601 Lexington Avenue
- 909 Third Avenue
- 299 Park Avenue
- 280 Park Avenue
- 55 East 52nd Street
- 599 Lexington Avenue
- 725 Fifth Avenue
- 731 Lexington Avenue
- 520 Madison Avenue
- 590 Madison Avenue
- 437 Madison Avenue
- 51 West 52nd Street
- 375 Park Avenue
- 885 Second Avenue
- 550 Madison Avenue
- 300 Park Avenue
- 320 Park Avenue
- 1230 Avenue of the Americas
- 31 West 52nd Street
- 425 Park Avenue
- 575 Lexington Avenue
- 40 West 57th Street
- 979 Third Avenue
- 12 East 49th Street
- 1 Rockefeller Plaza
- 757 Third Avenue
- 885 Third Avenue
- 875 Third Avenue
- 75 Rockefeller Plaza
- 65 East 55th Street
- 850 Third Avenue
- 110 East 59th Street
- 1350 Sixth Avenue
- 650 Madison Avenue
- 900 Third Avenue
- 350 Park Avenue
- 777 Third Avenue
- 825 Third Avenue
- 805 Third Avenue
- 535 Madison Avenue
- 150 East 58th Street
- 712 Fifth Avenue
- 745 Fifth Avenue
- 660 Madison Avenue
- 800 Third Avenue
- 1270 Avenue of the Americas
- 50 Rockefeller Plaza
- 575 Fifth Avenue
- 780 Third Avenue
- 717 Fifth Avenue
- 1330 Avenue Of The Americas
- 600 Fifth Avenue
- 570 Lexington Avenue
- 555 Madison Avenue
- 135 East 57th Street
- 641 Lexington Avenue
- 645 Fifth Avenue
- 750 Lexington Avenue
- 950 Third Avenue
- 444 Madison Avenue
- 650 Fifth Avenue
- 575 Madison Avenue
- 730 Fifth Avenue
- 488 Madison Avenue
- 560 Lexington Avenue
- 445 Park Avenue
- 600 Madison Avenue
- 580 Fifth Avenue
- 40 East 52nd Street
- 515 Madison Avenue
- 510 Madison Avenue
- 845 Third Avenue
- 623 Fifth Avenue
- 10 East 53rd Street
- 1370 Avenue of the Americas
- 450 Park Avenue
- 595 Madison Avenue
- 477 Madison Avenue
- 640 Fifth Avenue
- 711 Fifth Avenue
- 485 Madison Avenue
- 600 Lexington Avenue
- 767 Third Avenue
- 499 Park Avenue
- 150 East 52nd Street
- 10 Rockefeller Plaza
- 540 Madison Avenue
- 390 Park Avenue
- 125 W 57th St
- 1212 Avenue of the Americas
- 1011 First Avenue
- 460 Park Avenue
- 163-165 East 52nd Street
- 505 Park Avenue
- 130 East 59th Street
- 57 West 57th Street
- 425 East 61st Street
- 579 Fifth Avenue
- 14 East 60th Street
- 609 Fifth Avenue
- 30 East 60th Street
- 830 Third Avenue
- 133 East 58th Street
- 155 East 55th Street
- 15 West 47th Street
- 64 West 48th Street
- 18 East 48th Street
- 16 East 52nd Street
- 425 Madison Avenue
- 590 Fifth Avenue
- 48 West 48th Street
- 309-315 East 48th Street
- 328-330 East 62nd Street
- 24-26 West 57th Street
- 30 Central Park S
- 120 East 56th Street
- 71 West 47th Street
- 424 Madison Avenue
- 49-55 West 47th Street
- 306 East 61st Street
- 20 West 55th Street
- 592 Fifth Avenue
- 22 West 48th Street
- 37 West 57th Street
- 50 West 57th Street
- 110 East 55th Street
- 18-20 East 50th Street
- 724 Fifth Avenue
- 60 East 56th Street
- 42 West 48th Street
- 315 East 62nd Street
- 936-938 Third Avenue
- 145 East 57th Street
- 25 West 52nd Street
- 6 West 48th Street
- 20-24 East 60th Street
- 3-5 West 57th Street
- 232 East 59th Street
- 121 East 60th Street
- 7-9 West 51st Street
- 160 East 56th Street
- 420 Madison Avenue
- 5 East 57th Street
- 1114 First Avenue
- 5 East 59th Street
- 135 East 55th Street
- 587 Fifth Avenue
- 59 East 54th Street
- 215 East 58th Street
- 677 Fifth Avenue
- 155 East 48th Street
- 30 West 56th Street
- 139 East 57th Street
- 60 West 55th Street
- 49 West 57th Street
- 17 East 48th Street
- 1200 Avenue of the Americas
- 22 East 49th Street