Rent Midtown New York Medical
Expert Tenant Broker "No Fee"
We represent you, not the landlord
Direct
Sublease
coworking
Midtown Medical Office Listings
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | W 54th Street & Eleventh Avenue Floor 5 (full) | 32,500 | $ Negotiable | |
| B | E 45th Street & Second Avenue Floor 2 (full) | 15,000 | $ Negotiable | |
| A | Third Ave & East 41st Street Floor 8 (full) | 15,000 | $ Negotiable | |
| A | W 52nd Street & Avenue of the Americas Floor 5 (full) | 12,800 | $ Negotiable | |
| C | 11,300 | $ Negotiable | ||
| A | E 57th Street & Park Avenue Floor 16 (full) | 9,700 | $ 63,000 | |
| C | 9,000 | $ 42,600 | ||
| B | Fifth Ave & West 33rd Street Floor 5 (full) | 8,000 | $ 44,000 | |
| A | E 57th Street & Park Avenue Floor 5 | 5,800 | $ 36,000 | |
| C | W 36th Street & Broadway Floor 2 (full) | 5,500 | $ Negotiable | |
| C | W 57th Street & Seventh Avenue Floor 10 | 5,300 | $ 29,400 | |
| Medium Medical Offices for Rent | ||||
| B | Lexington Ave & East 33rd Street Floor 17 (full) | 4,900 | $ Negotiable | |
| A | Fifth Ave & East 54th Street Floor 18 (full) | 4,800 | $ Negotiable | |
| B | E 56th Street & Sixth Avenue Floor 10 (full) | 4,800 | $ Negotiable | |
| B | W 51st Street & Avenue of the Americas Floor 3 (full) | 4,300 | $ 23,400 | |
| A | Fifth Ave & East 38th Street Floor 6 | 4,200 | $ 14,400 | |
| C | E 32nd Street & Lexington Avenue Floor 11 (full) | 4,000 | $ Negotiable | |
| A | 3,900 | $ Negotiable | ||
| C | 3,800 | $ Negotiable | ||
| B | W 44th Street & Fifth Avenue Floor 11 | 3,500 | $ 18,000 | |
| A | 3,000 | $ 20,000 | ||
| Small Medical Offices for Rent | ||||
| B | 2,900 | $ Negotiable | ||
| A | 2,800 | $ 19,200 | ||
| B | 2,800 | $ Negotiable | ||
| C | W 32nd Street & Ninth Avenue Floor 14 | 2,800 | $ 11,600 | |
| A | 2,800 | $ Negotiable | ||
| B | W 57th Street & Avenue of the Americas Floor 20 (full) | 2,400 | $ 13,800 | |
| A | 2,300 | $ Negotiable | ||
| A | 2,100 | $ 17,000 | ||
| C | 2,100 | $ Negotiable | ||
| C | E 40th Street & Madison Avenue Penthouse | 2,000 | $ 11,600 | |
| C | W 51st Street & Tenth Avenue Basement | 1,800 | $ Negotiable | |
| B | W 60th Street & Eighth Avenue Lower level | 1,200 | $ 8,200 | |
| Large Medical Offices for Rent | ||||
| B | E 56th Street & East 55th Street Ground floor | 200 | $ 1,600 | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | 21,000 | $ Negotiable | ||
| A | Madison Ave & East 60th Street Floor 4 (full) | 10,700 | $ Negotiable | |
| B | E 56th Street & Madison Avenue Floor 2 (full) | 6,900 | $ 38,400 | |
| A | Madison Ave & East 59th Street Floor 14 | 6,600 | $ Negotiable | |
| B | Lexington Ave & East 41st Street Floor 10 (full) | 6,100 | $ 22,000 | |
| B | Madison Ave & East 35th Street Floor 2 (full) | 5,700 | $ Negotiable | |
| Medium Medical Offices for Rent | ||||
| B | E 56th Street & East 55th Street Ground floor | 4,000 | $ Negotiable | |
| C | 3,800 | $ Negotiable | ||
| B | 3,500 | $ 17,400 | ||
| Small Medical Offices for Rent | ||||
| B | 2,900 | $ Negotiable | ||
| A | 2,500 | $ Negotiable | ||
| A | 2,200 | $ Negotiable | ||
| B | 1,900 | $ 12,000 | ||
| B | Madison Ave & East 40th Street Floor 17 | 1,600 | $ Negotiable | |
| B | Central Park S & Broadway Floor 2 | 500 | $ 3,600 | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | E 58th Street & Park Avenue Plaza District · Floor 6 | 10,800 | $ Negotiable | |
| B | W 36th Street & Eighth Avenue Penn Plaza/Garment · Floor 9 (full) | 8,500 | $ Negotiable | |
| B | E 48th Street & Madison Avenue Plaza District · Floor 3 (full) | 8,000 | $ 43,200 | |
| B | Fifth Ave & West 47th Street Plaza District · Floor 7 (full) | 6,400 | $ 37,800 | |
| Medium Medical Offices for Rent | ||||
| B | E 46th Street & Fifth Avenue Grand Central · Floor 2 (full) | 4,800 | $ Negotiable | |
| B | W 45th Street & Avenue of the Americas Times Square · Floor 7 | 4,600 | $ Negotiable | |
| B | E 55th Street & Park Avenue Plaza District · Floor 10 (full) | 3,500 | $ 26,200 | |
| B | W 57th Street & Avenue of the Americas Columbus Circle · Floor 3 | 3,100 | $ 15,200 | |
| C | E 46th Street & Fifth Avenue Grand Central · Floor 2 | 3,000 | $ Negotiable | |
| Small Medical Offices for Rent | ||||
| B | E 57th Street & Lexington Avenue Plaza District · Floor 4 | 2,800 | $ Negotiable | |
| B | E 49th Street & Fifth Avenue Plaza District · Floor 6 (full) | 2,800 | $ Negotiable | |
| C | E 44th Street & Madison Avenue Grand Central · Floor 5 (full) | 2,700 | $ 10,000 | |
| A | E 57th Street & Fifth Avenue Plaza District · Floor 11 (full) | 2,700 | $ Negotiable | |
| C | Broadway & West 53rd Street Columbus Circle · Floor 6 | 1,900 | $ Negotiable | |
| A | Madison Ave & East 52nd Street Plaza District · Floor 28 (full) | 1,800 | $ Negotiable | |
| B | E 36th Street & Lexington Avenue Murray Hill · Ground floor | 1,600 | $ 9,000 | |
| C | Broadway & West 53rd Street Columbus Circle · Floor 6 | 1,400 | $ Negotiable | |
| B | E 60th Street & Madison Avenue Plaza District · Floor 11 | 1,400 | $ 8,600 | |
Excellent opportunities for medical space still exist if you know where to look. Optimal Spaces has a proven track record of securing these spaces for our clients on the best possible terms.
We are dedicated tenant brokers, meaning we exclusively represent your interests, never the landlord’s.
Why choose Optimal Spaces?
- Significant Savings: We typically save clients 10–15% compared with what they could negotiate on their own.
- Time Efficiency: We eliminate 100–200 hours of blind, unnecessary research for you.
- No Cost to You: Our service is provided at no fee to clients renting space.
- No Conflict of Interest: We represent only you, not the landlord.
Optimal Spaces consistently delivers exceptional spaces and advantageous deals for our clients. See their success: New York Medical Office Testimonials .
Why Optimal Spaces –
Tenant Broker
- No fee for clients renting space.
- We work for YOU, not the landlord.
- Save 10–15% on your business costs.
- Save 100–200 hours of research.
- Access to all available spaces.
- Specialized real estate expertise.
Alone or with other broker
- Miss deals and hard-to-find spaces.
- Potential conflict of interest (often represent landlords).
- Only 10% of available spaces are online.
- Lack of specialized expertise.
- May not get the best terms or uncover hidden costs.
1. The Crucial Distinction: Whose Side Are They On?
2. It Almost Always Costs You Nothing
3. Access to “Hidden” Inventory
4. Negotiating Beyond Base Rent
5. Time Savings & Process Management
6. Mitigating Risk (the “Gotchas”)
About Midtown
Midtown, one of the most vibrant neighborhoods in New York City, is a hub of business, entertainment, and culture. It is characterized by its iconic skyscrapers, bustling streets, and a variety of attractions that draw millions of visitors each year.
Geographic Boundaries
Midtown Manhattan extends in an L-shape from Bryant Park to Central Park, bordered by Fifth Avenue and Columbus Circle. This area is known for its high concentration of skyscrapers and serves as a central hub for New York City's business and entertainment sectors. The neighborhood is bounded by the East River to the east and the Hudson River to the west, though it does not directly border these rivers; instead, it is often differentiated from other areas by its bustling commercial activity and iconic landmarks.Businesses, Stores, Retailers, and Restaurants
Midtown is home to a diverse range of businesses, including some of the world's most prestigious corporate headquarters. It is a major shopping destination, with Fifth Avenue being one of the most famous shopping streets globally. The area features high-end retailers such as Saks Fifth Avenue, Tiffany & Co., and Bergdorf Goodman, as well as luxury boutiques and flagship stores for international brands. The neighborhood is also renowned for its fine dining experiences, with restaurants like Le Bernardin, Eleven Madison Park, and Carbone offering world-class cuisine. These establishments are frequently awarded Michelin stars and are popular among both locals and tourists for their exceptional service and culinary excellence.History of Major Attractions
Midtown is home to several iconic attractions that have been integral to its development over the years: - Times Square: Known as the "Crossroads of the World," Times Square is a dynamic area that is famous for its bright lights and giant billboards. Originally named Longacre Square, it was renamed Times Square in 1904 in honor of the New York Times, which relocated there. The area has undergone numerous transformations, including a major revitalization in the 1990s that transformed it into the vibrant entertainment district it is today. - Empire State Building: Completed in 1931, the Empire State Building is one of the most iconic skyscrapers in the world. It held the title of the world's tallest building for nearly 40 years and is a symbol of New York City's engineering prowess and architectural innovation. - Rockefeller Center: This complex of buildings is a significant part of Midtown's history and is best known for its ice skating rink and Christmas tree lighting ceremony. It was developed by John D. Rockefeller Jr. and has been a hub for media and entertainment since its construction began in the 1930s. - Broadway Theater District: Midtown hosts the world-famous Broadway theater district, where numerous world-class performances are held. The area is home to over 40 professional theaters, each offering a unique theatrical experience that attracts audiences from around the globe.Types of Buildings
Midtown is characterized by its high-rise buildings and iconic skyscrapers, including the Bank of America Tower and the Empire State Building. The area also features historic buildings like the Chrysler Building and the New York Public Library's Beaux-Arts building. These structures not only reflect the area's architectural diversity but also its role as a hub for business and cultural activities.Other Significant Buildings
- Chrysler Building: Completed in 1930, this Art Deco skyscraper is one of the most recognizable buildings in New York City. Its distinctive design and elegant appearance make it a beloved landmark. - Grand Central Terminal: Though not exclusively within Midtown's boundaries, Grand Central is a nearby iconic transportation hub and a major landmark in New York City. It is known for its grand architecture and vibrant atmosphere, offering both a bustling commute hub and a popular tourist destination. - United Nations Headquarters: Located in the Turtle Bay neighborhood within Midtown, the United Nations complex serves as a symbol of international cooperation and diplomacy.Transportation Options
Midtown offers a variety of transportation options, including several major subway lines and bus routes. The area is easily accessible via the New York City Subway, with key stations like Times Square – 42nd Street and Grand Central Terminal providing convenient connections throughout the city. Additionally, Midtown is close to major transportation hubs like Penn Station and Grand Central Terminal, making it a central point for both local and regional travel.Adjacent Zip Codes
Midtown Manhattan is surrounded by several zip codes, including 10001, 10017, 10019, and 10036. These zip codes are part of the larger area but are not exhaustive, as Midtown stretches across multiple zip code boundaries.Prominent Companies and Businesses
Midtown is home to numerous prominent companies across various industries. Major media conglomerates, financial institutions, and multinational corporations have headquarters in the area. Some of the notable companies with offices in Midtown include: - Media and Entertainment: Companies like NBCUniversal, ViacomCBS, and Condé Nast have significant operations in Midtown, leveraging the area's status as a global media hub. - Financial Services: Major financial institutions such as Bank of America have headquarters in Midtown, taking advantage of the area's proximity to Wall Street and other financial centers. - Technology and Advertising: Companies like Google and major advertising agencies are also based in Midtown, benefiting from the neighborhood's vibrant business environment. Overall, Midtown Manhattan is a dynamic neighborhood that offers a blend of business, entertainment, and culture, making it one of the most iconic and visited areas in the world.Office Buildings in Midtown
- 200 Park Avenue
- 50 Hudson Yards
- 350 Fifth Avenue
- 435 Tenth Avenue
- 1633 Broadway
- 630 Fifth Avenue
- 1 Penn Plaza
- 1221 Avenue of the Americas
- 30 Hudson Yards
- 1251 Avenue of the Americas
- 1 Bryant Park
- 30 Rockefeller Plaza
- 1290 Avenue of the Americas
- 767 Fifth Avenue
- 825 Eighth Avenue
- 400 West 33rd Street
- 1211 Avenue of the Americas
- 1345 Avenue of the Americas
- 345 Park Avenue
- 385 9th Avenue
- 1271 Avenue of the Americas
- 3 Hudson Boulevard
- One Columbus Circle
- 277 Park Avenue
- 10 Hudson Yards
- 620 Eighth Avenue
- 2 Penn Plaza
- 151 West 42nd Street
- 245 Park Avenue
- 1301-1315 Avenue of the Americas
- One Vanderbilt Avenue
- 1515 Broadway
- 399 Park Avenue
- 150 East 42nd Street
- 9 West 57th Street
- 1166 Avenue of the Americas
- 787 Seventh Avenue
- 1285 Avenue of the Americas
- 335 Madison Avenue
- 450 West 33rd Street
- 1114 Avenue of the Americas
- 550 West 34th Street
- 660 Fifth Avenue
- 420 Lexington Avenue
- 1095 Avenue of the Americas
- 1585 Broadway
- 919 Third Avenue
- 601 Lexington Avenue
- 3 Park Avenue
- 230 Park Avenue
- 909 Third Avenue
- 299 Park Avenue
- 101 Park Avenue
- 280 Park Avenue
- 7 Times Square
- 237 Park Avenue
- 1411 Broadway
- 375-391 Madison Ave
- 2 Park Avenue
- 1540 Broadway
- 5 Times Square
- 55 East 52nd Street
- 11 Penn Plaza
- 300 Madison Avenue
- 220 East 42nd Street
- 11 Times Square
- 599 Lexington Avenue
- 1133 Avenue of the Americas
- 1185 Avenue of the Americas
- 1407 Broadway
- 725 Fifth Avenue
- 731 Lexington Avenue
- 520 Madison Avenue
- 590 Madison Avenue
- 555 West 57th Street
- 405 Lexington Avenue
- 745 Seventh Avenue
- 622 Third Avenue
- 90 Park Avenue
- 498 Seventh Avenue
- 11 West 42nd Street
- 3 Times Square
- 450 Lexington Avenue
- 343 Madison Ave
- 511 West 35th Street
- One Park Avenue
- 485 Lexington Avenue
- 437 Madison Avenue
- 235 East 42nd Street
- 135 West 50th Street
- 1400 Broadway
- 51 West 52nd Street
- 1177 Avenue of the Americas
- 100 Park Avenue
- 605 Third Avenue
- 188-198 Madison Avenue
- 375 Park Avenue
- 888 7th Avenue
- 1501 Broadway
- 1675 Broadway
- 811 Tenth Avenue
- 60 East 42nd Street
- 100-126 West 33rd Street
- 1335 Avenue Of The Americas
- 633 Third Avenue
- 122 East 42nd Street
- 520 Eighth Avenue
- 125 Park Avenue
- 500 7th Avenue
- 1740 Broadway
- 711 Third Avenue
- 14 Penn Plaza
- 1372 Broadway
- 260 Madison Avenue
- 512 Seventh Avenue
- 275 Madison Avenue
- 205 East 42nd Street
- 636 11th Avenue
- 1385 Broadway
- 521-533 West 57th Street
- 450 Seventh Avenue
- 200 Lexington Avenue
- 463 Seventh Avenue
- 671-683 First Avenue
- 10 West 33rd Street
- 1412 Broadway
- 551 Fifth Avenue
- 440 Ninth Ave
- 525 Seventh Avenue
- 530 Seventh Avenue
- 295 Madison Avenue
- 1011 First Avenue
- 28 West 44th Street
- 132 West 31st Street
- 950 6th Avenue
- 368 Ninth Avenue
- 481 Eighth Avenue
- 16 East 34th Street
- 652 West 57th Street
- 1430 Broadway
- 1333 Broadway
- 333 West 34th Street
- 460 Park Avenue
- 270 West 38th Street
- 619 West 54th Street
- 304 East 45th Street
- 307 West 38th Street
- 1900 Broadway
- 1755 Broadway
- 417 Fifth Avenue
- 136 Madison Avenue
- 31 West 34th Street
- 163-165 East 52nd Street
- 423 West 55th Street
- 110 East 42nd Street
- 505 Eighth Avenue
- 180 Madison Avenue
- 183 Madison Avenue
- 30 West 32nd Street
- 475 Fifth Avenue
- 630 Ninth Avenue
- 1370 Broadway
- 247 West 37th Street
- 550 Seventh Avenue
- 469 Seventh Avenue
- 875 Avenue of the Americas
- 302-306 West 39th Street
- 17-19 West 34th Street
- 475 Tenth Avenue
- 1 Herald Square
- 1040 Avenue of the Americas
- 307 West 36th Street
- 130 West 42nd Street
- 321 West 44th Street
- 1460 Broadway
- 500 Eighth Avenue
- 220 West 42nd Street
- 1001 Avenue of the Americas
- 401 Fifth Avenue
- 354 West 54th Street
- 1560 Broadway
- 575 Eighth Avenue
- 505 Park Avenue
- 228 East 45th Street
- 130 East 59th Street
- 330 Fifth Avenue
- 820 Second Avenue
- 5 Columbus Circle
- 270 Madison
- 34 West 33rd Street
- 462-468 Seventh Avenue
- 211 East 43rd Street
- 250 West 39th Street
- 215 Lexington Avenue
- 235 East 45th Street
- 555 Fifth Avenue
- 25 West 39th Street
- 116-120 West 32nd Street
- 1384 Broadway
- 213 West 35th Street
- 519 Eighth Avenue
- 55 East 59th Street
- 231-249 West 39th Street
- 265-269 West 37th Street
- 205 West 39th Street
- 62-72 West 47th Street
- 330 West 38th Street
- 80 West End Avenue
- 132-138 West 36th Street
- 242-252 West 36th Street
- 263 West 38th Street
- 1231 Broadway
- 511 Fifth Avenue
- 224 West 35th Street
- 257-267 West 39th Street
- 20-28 West 33rd Street
- 260 West 39th Street
- 42 West 39th Street
- 336-342 West 37th Street
- 48 West 37th Street
- 33 East 33rd Street
- 38-40 West 32nd Street
- 862 Avenue of the Americas
- 225 West 37th Street
- 555 Eighth Avenue
- 252-258 West 37th Street
- 237 West 35th Street
- 513 West 56th Street
- 253 West 35th Street
- 1-13 East 33rd Street
- 629-641 West 54th Street
- 229 West 36th Street
- 230 West 38th Street
- 223-225 West 35th Street
- 320 West 31st Street
- 1261 Broadway
- 36 East 31st Street
- 247 West 38th Street
- 1237-1239 Broadway
- 535-547 West 45th Street
- 200 West 57th Street
- 248 West 35th Street
- 315-321 West 39th Street
- 520 West 49th Street
- 211 West 61st Street
- 48 West 38th Street
- 320-324 West 37th Street
- 347 West 36th Street
- 33 West 60th Street
- 134-142 West 37th Street
- 148 West 37th Street
- 450 West 31st Street
- 22 West 32nd Street
- 333 West 52nd Street
- 259 West 30th Street
- 43-51 West 36th Street
- 260 West 36th Street
- 21 West 46th Street
- 55 West 39th Street
- 10 East 39th Street
- 246 West 38th Street
- 145 West 30th Street
- 247 West 35th Street
- 225 West 39th Street
- 151 West 30th Street
- 131 West 35th Street
- 44 East 32nd Street
- 39 West 32nd Street
- 226 West 37th Street
- 38 East 32nd Street
- 3 West 35th Street
- 37 West 47th Street
- 212-216 West 35th Street
- 20 West 36th Street
- 1 East 60TH Street
- 29 West 30th Street
- 15 West 39th Street
- 437 Fifth Avenue
- 270-276 West 39th Street
- 599 Eleventh Avenue
- 14 East 38th Street
- 257-261 West 38th Street
- 363 Seventh Avenue
- 580 Eighth Avenue
- 306 West 38th Street
- 49 West 38th Street
- 215 West 40th Street
- 350 West 31st Street
- 420 West 45th Street
- 31 East 32nd Street
- 22 West 38th Street
- 260 West 35th Street
- 250 West 40th Street
- 22-30 West 34th Street
- 230 West 39th Street
- 1220 Broadway
- 7 West 30th Street
- 16-18 West 36th Street
- 37 West 37th Street
- 19-21 West 36th Street
✔ We represent only Tenants.
✔ We bid landlords against each other to save you 10-15%.
✔ Weed out bad spaces saving you 100-200 hours.
Contact Us
- Home
- Rent Office By Zip Code
- Rent Office Class A
- Rent Office Class B
- Rent Office Class C
- Rent Office By Neighborhood
✓ 700+ locations in NYC
✓ Let Optimal find the best space and best deal for you.
✓ No Fee!!
✓ Great results and proven track record.






