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New York Medical Office Listings
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | William St & Beekman Street Floor 5 (full) | 24,000 | $ Negotiable | |
| B | E 45th Street & Second Avenue Floor 2 (full) | 15,000 | $ Negotiable | |
| A | Third Ave & East 41st Street Floor 8 (full) | 15,000 | $ Negotiable | |
| C | 11,300 | $ Negotiable | ||
| A | E 57th Street & Park Avenue Floor 16 (full) | 9,700 | $ 63,000 | |
| A | E 56th Street & Madison Avenue Floor 4 (full) | 6,500 | $ Negotiable | |
| B | Fifth Ave & West 47th Street Floor 6 (full) | 6,400 | $ 34,600 | |
| A | E 57th Street & Park Avenue Floor 5 | 5,800 | $ 36,000 | |
| B | 5,400 | $ 29,200 | ||
| C | W 36th Street & Broadway Floor 3 (full) | 5,000 | $ 12,000 | |
| Medium Medical Offices for Rent | ||||
| A | Fifth Ave & East 54th Street Floor 18 (full) | 4,800 | $ Negotiable | |
| B | E 56th Street & Sixth Avenue Floor 10 (full) | 4,800 | $ Negotiable | |
| B | E 48th Street & Madison Avenue Floor 12 (full) | 4,700 | $ Negotiable | |
| B | W 51st Street & Avenue of the Americas Floor 3 (full) | 4,300 | $ 23,400 | |
| A | Broadway & West 41st Street Floor 24 | 3,700 | $ Negotiable | |
| B | W 44th Street & Fifth Avenue Floor 11 | 3,500 | $ 18,000 | |
| C | E 46th Street & Fifth Avenue Floor 2 | 3,000 | $ Negotiable | |
| Small Medical Offices for Rent | ||||
| B | 2,800 | $ Negotiable | ||
| C | W 32nd Street & Ninth Avenue Floor 14 | 2,800 | $ 11,600 | |
| A | 2,800 | $ Negotiable | ||
| B | E 49th Street & Fifth Avenue Floor 6 (full) | 2,800 | $ Negotiable | |
| A | Broad St & Exchange Place Floor 6 | 2,600 | $ 5,400 | |
| A | 2,300 | $ Negotiable | ||
| A | 2,100 | $ 17,000 | ||
| C | 2,100 | $ Negotiable | ||
| C | 2,000 | $ Negotiable | ||
| B | E 40th Street & Madison Avenue Penthouse | 1,500 | $ 9,000 | |
| C | E 40th Street & Madison Avenue Floor 10 | 1,400 | $ 8,000 | |
| B | 1,100 | $ 5,800 | ||
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| A | Madison Ave & East 60th Street Floor 4 (full) | 10,700 | $ Negotiable | |
| B | E 56th Street & Madison Avenue Floor 2 (full) | 6,900 | $ 38,400 | |
| A | Madison Ave & East 59th Street Floor 14 (full) | 6,600 | $ Negotiable | |
| B | Lexington Ave & East 41st Street Floor 10 (full) | 6,100 | $ 22,000 | |
| B | Broad St & Exchange Place Floor 6 | 5,600 | $ Negotiable | |
| Medium Medical Offices for Rent | ||||
| B | 3,500 | $ 17,400 | ||
| Small Medical Offices for Rent | ||||
| A | 2,500 | $ Negotiable | ||
| B | 1,900 | $ 12,000 | ||
| B | Madison Ave & East 40th Street Floor 17 | 1,600 | $ Negotiable | |
| B | E 41st Street & Fifth Avenue Floor 11 | 1,400 | $ Negotiable | |
| A | E 57th Street & Park Avenue Floor 6 | 1,000 | $ Negotiable | |
| B | 1,000 | $ 5,000 | ||
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | E 58th Street & Park Avenue Plaza District · Floor 6 | 10,800 | $ Negotiable | |
| B | W 57th Street & Avenue of the Americas Plaza District · Floor 4 (full) | 9,000 | $ 34,400 | |
| B | W 36th Street & Eighth Avenue Penn Plaza/Garment · Floor 9 (full) | 8,500 | $ Negotiable | |
| Medium Medical Offices for Rent | ||||
| B | E 46th Street & Fifth Avenue Grand Central · Floor 2 (full) | 4,800 | $ Negotiable | |
| B | W 45th Street & Avenue of the Americas Times Square · Floor 7 | 4,600 | $ Negotiable | |
| B | Lexington Ave & Lexington Avenue Plaza District · Floor 4 (full) | 4,600 | $ 16,200 | |
| B | E 55th Street & Park Avenue Plaza District · Floor 10 (full) | 3,500 | $ 26,200 | |
| Small Medical Offices for Rent | ||||
| B | E 57th Street & Lexington Avenue Plaza District · Floor 4 | 2,800 | $ Negotiable | |
| C | E 44th Street & Madison Avenue Grand Central · Floor 5 (full) | 2,700 | $ 10,000 | |
| A | E 57th Street & Fifth Avenue Plaza District · Floor 11 (full) | 2,700 | $ Negotiable | |
| B | Madison Ave & East 41st Street Grand Central · Floor 4 | 2,600 | $ 13,000 | |
| B | W 57th Street & Avenue of the Americas Plaza District · Floor 20 (full) | 2,400 | $ 13,800 | |
| B | E 44th Street & Third Avenue Grand Central · Floor 1 | 2,400 | $ Negotiable | |
| A | Madison Ave & East 52nd Street Plaza District · Floor 28 (full) | 1,800 | $ Negotiable | |
Medical Tenants Rented / Leased New York
- Norman Marcus Pain Institute leased 3,000 SF at 30 E 40th St
- Kerato leased 3,000 SF at 160 E 56th St
- The Fragrance Foundation leased 2,450 SF at 60 E 56th St
- Umbareen Mahmood, MD leased 2,400 SF at 5 E 57th St
- Private Medical leased 2,312 SF at 110 E 60th St
- Les Belles NYC Dentistry leased 2,250 SF at 110 E 60th St
- Ageless Youth By Renata leased 2,220 SF at 160 E 56th St
- Omid Nikrouz, MD. PC. leased 2,152 SF at 133 E 58th St
- Dr. Joshua Levine, MD, PC leased 2,000 SF at 57 W 57th St
- 501 Restorative leased 1,750 SF at 501 Madison Ave
- NYC Periodontics & Implant Dentistry leased 1,750 SF at 501 Madison Ave
- Midtown East Medical leased 1,653 SF at 120 E 56th St
- JCG Weight Loss & Wellness leased 1,617 SF at 133 E 58th St
- ITS Academy leased 265 SF at 635 Madison Ave
Excellent opportunities for medical space still exist if you know where to look. Optimal Spaces has a proven track record of securing these spaces for our clients on the best possible terms.
We are dedicated tenant brokers, meaning we exclusively represent your interests, never the landlord’s.
Why choose Optimal Spaces?
- Significant Savings: We typically save clients 10–15% compared with what they could negotiate on their own.
- Time Efficiency: We eliminate 100–200 hours of blind, unnecessary research for you.
- No Conflict of Interest: We represent only you, not the landlord.
Optimal Spaces consistently delivers exceptional spaces and advantageous deals for our clients. See their success: New York Medical Office Testimonials .
Why Optimal Spaces Tenant Broker
- Lease negotiation: full terms, renewals, expansion options
- Cost analysis, inventory identification, negotiating scope
- Risk mitigation against hidden pitfalls
Cost Savings
- Negotiate 30+ leasing points to prevent hidden costs
- Save 10–15% on total leasing costs
- Save 100–200 hours filtering unviable spaces
- Property access via broker databases and networks (off-market, subleases, future availability)
Alone or With Other Brokers
- Managing agents owe a fiduciary duty to landlords, seeking maximum price and terms rather than tenant savings.
- Inherent conflict of interest as most brokers represent landlords
- Risk of weaker terms and overlooked hidden costs
- Heavy workload falls on you while best spaces are missed
About New York
New York City, often referred to as the "City That Never Sleeps," is a vibrant metropolis with diverse neighborhoods, each offering unique experiences and attractions. The term "New York" can sometimes refer to the broader city, but in this context, we will focus on Manhattan, one of the five boroughs, which is often what people mean when they say "New York." This article will explore the geographic boundaries, businesses, history, architecture, transportation, and significant buildings in Manhattan, which is at the heart of New York City.
Geographic Boundaries
Manhattan is bounded by the Hudson River to the west, the East River to the east, the Harlem River to the north, and the New York Harbor to the south. It is the smallest yet most densely populated borough of New York City, covering an area of approximately 22.82 square miles. The neighborhood boundaries within Manhattan are often defined by community districts, which are used to organize local government and community services. These boundaries are typically defined by a combination of historical, cultural, and administrative factors.
Description of Businesses, Stores, Retailers, and Fine Restaurants
Manhattan is renowned for its diverse range of businesses, from high-end retailers to family-owned eateries. Major commercial districts include Times Square, known for its bright lights and bustling atmosphere, and the Garment District, a hub for fashion and textiles. The shopping experience in Manhattan is unlike anywhere else, with iconic department stores like Macy's and Bloomingdale's offering a wide range of products. Fifth Avenue is famous for luxury brands like Tiffany & Co. and Saks Fifth Avenue.
Manhattan is also home to some of the world's finest restaurants, offering cuisine from almost every culture. Michelin-starred restaurants like Eleven Madison Park and Le Bernardin are must-visits for food enthusiasts. The neighborhood is dotted with trendy cafes and bars, particularly in areas like SoHo, Greenwich Village, and the Upper East Side.
History of Major Attractions
Manhattan is filled with historical landmarks and cultural attractions that draw millions of visitors each year. The Statue of Liberty, located on Liberty Island but closely associated with Manhattan, is a symbol of American freedom and democracy. Central Park, designed by Frederick Law Olmsted and Calvert Vaux, offers a peaceful escape from the city's hustle and bustle. The Metropolitan Museum of Art, one of the world's largest art museums, is a major cultural institution located along the park.
The 9/11 Memorial & Museum, located in Lower Manhattan, is a tribute to the victims of the September 11 attacks. The Empire State Building, completed in 1931, is an iconic skyscraper and one of the city's most recognizable landmarks. Times Square, known for its New Year's Eve celebrations, is a hub for entertainment and nightlife.
Types of Buildings
Manhattan's architecture is a mix of old and new, reflecting its rich history and continuous development. The borough is home to some of the oldest buildings in the United States, such as the St. Patrick's Cathedral, built in the mid-19th century, and the historic brownstone houses in the Upper East Side and Greenwich Village.
Skyscrapers dominate the Manhattan skyline, with iconic buildings like the Chrysler Building and the One World Trade Center being among the tallest in the world. The borough also features modern residential complexes and luxury high-rise apartments, particularly in areas like Hudson Yards and the Financial District.
Other Significant Buildings
Manhattan is home to many significant buildings beyond its iconic skyscrapers. The New York Public Library, a Beaux-Arts building completed in 1911, is a masterpiece of American architecture. The Flatiron Building, built in 1902, is a unique triangular structure that has become a symbol of New York City. The United Nations Headquarters, located along the East River, is a symbol of international diplomacy and cooperation.
Transportation Options
Manhattan offers a comprehensive network of transportation options, making it easy to navigate the borough. The New York City Subway system is one of the largest in the world, providing 24/7 service to most areas of Manhattan. The subway is complemented by a fleet of buses and the MTA's Select Bus Service, offering express routes to major destinations.
Manhattan is also accessible by car, with several major highways passing through the borough, including the Lincoln Tunnel and the Queens-Midtown Expressway. Bike lanes and pedestrian paths are increasingly popular, with initiatives like the Hudson River Greenway offering scenic routes along the river.
Adjacent Zip Codes
Manhattan's zip codes range from 10001 to 10282. Some of the most notable zip codes include 10021 for the Upper East Side, 10011 for Chelsea, and 10012 for Greenwich Village. These zip codes are often used to define specific neighborhoods or areas within Manhattan.
Prominent Companies
Manhattan is a hub for many prominent companies across various industries. Financial institutions like Goldman Sachs and JPMorgan Chase have headquarters in Manhattan, specifically in the Financial District. Media giants such as NBCUniversal and The New York Times are also based in the borough, with NBC's headquarters in Rockefeller Center and The New York Times in Midtown.
Manhattan is also home to major tech companies, including Google and Facebook (Meta), which have significant offices in the Hudson Square area. The city is a major center for law firms, with many of the world's top legal firms having offices in Midtown and the Financial District.
Overall, Manhattan's diverse mix of businesses, historical landmarks, and cultural attractions make it a vibrant and exciting place to live and visit.
Office Buildings in New York
- 55 Water Street
- 200 Park Avenue
- 50 Hudson Yards
- 350 Fifth Avenue
- 435 Tenth Avenue
- 630 Fifth Avenue
- 1 Penn Plaza
- 1221 Avenue of the Americas
- 30 Hudson Yards
- 1 New York Plaza
- 1251 Avenue of the Americas
- 1 Bryant Park
- 30 Rockefeller Plaza
- 28 Liberty Street
- 1290 Avenue of the Americas
- 767 Fifth Avenue
- 825 Eighth Avenue
- 400 West 33rd Street
- 1211 Avenue of the Americas
- 345 Park Avenue
- 385 9th Avenue
- 120 Broadway
- 3 Hudson Boulevard
- 388 Greenwich Street
- 277 Park Avenue
- 10 Hudson Yards
- 620 Eighth Avenue
- 2 Penn Plaza
- 151 West 42nd Street
- 245 Park Avenue
- One Vanderbilt Avenue
- 1515 Broadway
- 399 Park Avenue
- 150 East 42nd Street
- 9 West 57th Street
- 1166 Avenue of the Americas
- 335 Madison Avenue
- 2 Broadway
- 450 West 33rd Street
- 1114 Avenue of the Americas
- 550 West 34th Street
- 60 Wall Street
- 660 Fifth Avenue
- 420 Lexington Avenue
- 1095 Avenue of the Americas
- 1585 Broadway
- 140 Broadway
- 125 Broad Street
- 919 Third Avenue
- 601 Lexington Avenue
- 230 Park Avenue
- 909 Third Avenue
- 299 Park Avenue
- 101 Park Avenue
- 280 Park Avenue
- 7 Times Square
- 237 Park Avenue
- 1411 Broadway
- 375-391 Madison Ave
- 180 Maiden Ln
- 1540 Broadway
- 32 Avenue of the Americas
- 5 Times Square
- 32 Old Slip
- 199 Water Street
- 55 East 52nd Street
- 11 Penn Plaza
- 300 Madison Avenue
- 220 East 42nd Street
- 4 New York Plaza
- 11 Times Square
- 599 Lexington Avenue
- 80 Pine Street
- 1133 Avenue of the Americas
- 1185 Avenue of the Americas
- 1407 Broadway
- 725 Fifth Avenue
- 59 Maiden Ln
- 40 Wall Street
- 731 Lexington Avenue
- 520 Madison Avenue
- 590 Madison Avenue
- 14 Wall Street
- 405 Lexington Avenue
- 745 Seventh Avenue
- 60 Broad Street
- 85 Broad Street
- 622 Third Avenue
- 100 Pearl St
- 90 Park Avenue
- 111 Wall Street
- 498 Seventh Avenue
- 11 West 42nd Street
- 3 Times Square
- 450 Lexington Avenue
- 343 Madison Ave
- 511 West 35th Street
- 485 Lexington Avenue
- 437 Madison Avenue
- 235 East 42nd Street
- 60 East 42nd Street
- 60 Hudson Street
- 100-126 West 33rd Street
- 633 Third Avenue
- 122 East 42nd Street
- 520 Eighth Avenue
- 40 Worth Street
- 11 Wall Street
- 125 Park Avenue
- 33 Liberty Street
- 500 7th Avenue
- 711 Third Avenue
- 150 William Street
- 14 Penn Plaza
- 1372 Broadway
- 80 Maiden Ln
- 260 Madison Avenue
- 512 Seventh Avenue
- 275 Madison Avenue
- 205 East 42nd Street
- 636 11th Avenue
- 1385 Broadway
- 1-11 Bridge Street
- 450 Seventh Avenue
- 160 Water Street
- 463 Seventh Avenue
- 30 Broad Street
- 10 West 33rd Street
- 1412 Broadway
- 551 Fifth Avenue
- 80 Broad Street
- 90 Broad Street
- 440 Ninth Ave
- 525 Seventh Avenue
- 530 Seventh Avenue
- 295 Madison Avenue
- 1011 First Avenue
- 28 West 44th Street
- 132 West 31st Street
- 200 Hudson Street
- 950 6th Avenue
- 368 Ninth Avenue
- 481 Eighth Avenue
- 50 Broadway
- 1430 Broadway
- 1333 Broadway
- 44 Wall Street
- 90 John Street
- 333 West 34th Street
- 111 John Street
- 460 Park Avenue
- 5 Hanover Square
- 270 West 38th Street
- 307 West 38th Street
- 31 West 34th Street
- 40 Exchange Place
- 163-165 East 52nd Street
- 110 East 42nd Street
- 505 Eighth Avenue
- 30 West 32nd Street
- 475 Fifth Avenue
- 50 Broad Street
- 630 Ninth Avenue
- 1370 Broadway
- 247 West 37th Street
- 550 Seventh Avenue
- 469 Seventh Avenue
- 875 Avenue of the Americas
- 302-306 West 39th Street
- 17-19 West 34th Street
- 475 Tenth Avenue
- 1 Herald Square
- 1040 Avenue of the Americas
- 156 William Street
- 307 West 36th Street
- 130 West 42nd Street
- 321 West 44th Street
- 150 Broadway
- 1460 Broadway
- 35 Wall Street
- 500 Eighth Avenue
- 220 West 42nd Street
- 1001 Avenue of the Americas
- 1560 Broadway
- 575 Eighth Avenue
- 505 Park Avenue
- 137 Hudson Street
- 228 East 45th Street
- 130 East 59th Street
- 330 Fifth Avenue
- 270 Madison
- 34 West 33rd Street
- 462-468 Seventh Avenue
- 211 East 43rd Street
- 250 West 39th Street
- 235 East 45th Street
- 555 Fifth Avenue
- 25 West 39th Street
- 116-120 West 32nd Street
- 1384 Broadway
- 205 Hudson Street
- 519 Eighth Avenue
- 42 Broadway
- 55 East 59th Street
- 231-249 West 39th Street
- 265-269 West 37th Street
- 205 West 39th Street
- 62-72 West 47th Street
- 330 West 38th Street
- 132-138 West 36th Street
- 242-252 West 36th Street
- 263 West 38th Street
- 1231 Broadway
- 511 Fifth Avenue
- 224 West 35th Street
- 257-267 West 39th Street
- 20-28 West 33rd Street
- 260 West 39th Street
- 42 West 39th Street
- 336-342 West 37th Street
- 48 West 37th Street
- 38-40 West 32nd Street
- 862 Avenue of the Americas
- 225 West 37th Street
- 555 Eighth Avenue
- 252-258 West 37th Street
- 237 West 35th Street
- 253 West 35th Street
- 229 West 36th Street
- 230 West 38th Street
- 223-225 West 35th Street
- 320 West 31st Street
- 1261 Broadway
- 32 Broadway
- 247 West 38th Street
- 1237-1239 Broadway
- 535-547 West 45th Street
- 248 West 35th Street
- 315-321 West 39th Street
- 520 West 49th Street
- 48 West 38th Street
- 320-324 West 37th Street
- 347 West 36th Street
- 134-142 West 37th Street
- 148 West 37th Street
- 450 West 31st Street
- 22 West 32nd Street
- 157 Chambers Street
- 259 West 30th Street
- 43-51 West 36th Street
- 260 West 36th Street
- 21 West 46th Street
- 55 West 39th Street
- 10 East 39th Street
- 246 West 38th Street
- 145 West 30th Street
- 247 West 35th Street
- 225 West 39th Street
- 11 Hanover Square
- 151 West 30th Street
- 131 West 35th Street
- 39 West 32nd Street
- 226 West 37th Street
- 3 West 35th Street
- 37 West 47th Street
- 212-216 West 35th Street
- 20 West 36th Street
- 1 East 60TH Street
- 29 West 30th Street
- 15 West 39th Street
- 437 Fifth Avenue
- 270-276 West 39th Street
- 599 Eleventh Avenue
- 257-261 West 38th Street
- 363 Seventh Avenue
- 580 Eighth Avenue
- 306 West 38th Street
- 49 West 38th Street
- 215 West 40th Street
- 350 West 31st Street
- 420 West 45th Street
- 22 West 38th Street
- 260 West 35th Street
- 250 West 40th Street
- 22-30 West 34th Street
- 230 West 39th Street
- 1220 Broadway
- 7 West 30th Street
- 16-18 West 36th Street
- 37 West 37th Street
- 19-21 West 36th Street
- 39-41 West 38th Street
- 54 West 39th Street
- 16 Vestry Street
- 286-288 Fifth Avenue
- 34-36 West 32nd Street
- 109 West 38th Street
- 11 West 32nd Street
- 149 West 36th Street
- 110 West 34th Street