Expert Tenant Broker "No Fee"
We represent you, not the landlord

Rent Office 345 Park Avenue South

Lease Office 345 Park Avenue South

$ / SF SF Monthly Rent
Negotiable
11,600
Negotiable
Please notify me when a new space is available
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent

Nearby Sublease office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Park Ave S & Between East 19th Street $ 60
7,700
$ 38,500
Fifth Ave & East 19th Street $ 77
8,800
$ 56,466
Fifth Ave & East 16th Street $ 42
10,100
$ 35,350
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Type of Space Class A/month Class B/month Class C/month
Windowed office/person $ 2596 $ 1300 $ 775
Interior office/person $ 1846 $ 800 $ 525
Team Rooms $ 10596 $ 8050 $ 5025
Suites $ 20596 $ 12050 $ 7025

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 92
9,100
$ 69,766
Park Ave S & East 20th Street $ 81
13,000
$ 87,750
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street $ 96
4,000
$ 32,166
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 61
8,300
$ 42,191
E 23rd St & Park Avenue $ 42
18,400
$ 63,633
Broadway & East 20th Street $ 70
18,200
$ 106,925
Park Ave S & Between East 19th Street $ 67
7,700
$ 42,991
Park Ave S & East 27th Street $ 75
8,700
$ 54,375
Fifth Ave & East 29th Street $ 79
12,500
$ 82,291
Park Ave S & East 27th Street $ 70
13,100
$ 75,870
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Park Ave S & East 26th Street $ 48
12,000
$ 48,500
Broadway & Between East 13th Street $ 71
12,700
$ 75,141
Madison Ave & East 28th Street $ 40
18,500
$ 61,666
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 42
6,100
$ 21,350
Broadway & East 20th Street $ 76
3,700
$ 23,433
Fifth Ave & East 29th Street $ 73
4,700
$ 28,591
Park Ave S & East 26th Street $ 75
2,700
$ 16,875
University Pl & East 12th Street $ 50
6,500
$ 27,083
Broadway & East 18th Street $ 72
2,500
$ 15,104
Address $ / SF SF Monthly Rent
E 23rd St & Third Avenue $ 44
2,400
$ 8,900
Park Ave S & East 26th Street $ 62
2,100
$ 10,850
Broadway & East 18th Street $ 72
1,800
$ 10,875
Address $ / SF SF Monthly Rent
Madison Ave & East 30th Street $ 40
11,000
$ 36,208
E 23rd St & Lexington Avenue $ 68
21,600
$ 121,500
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway $ 54
5,500
$ 24,979
Fifth Ave & East 29th Street $ 59
2,500
$ 12,291
Fifth Ave & Between East 28th Street $ 52
5,000
$ 21,875
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 38
2,300
$ 7,187
Broadway & East 21st Street $ 74
1,800
$ 11,025

Retail Spaces for Rent at 345 Park Avenue South

Rent Medical Space at 345 Park Avenue South

Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 345 Park Avenue South. This trend is projected to continue. Opportunities for subleases remain available at 345 Park Avenue South and in the nearby Gramercy Park neighborhood.
Find My Space!
345 Park Avenue South nyc
Thank you! we will be in touch.

Before you go please fill:



Search all rental options at 345 Park Avenue South

345 Park Avenue South Property Overview

Building Address: 345 Park Avenue South, New York NY 10010
Building Name: The Iselin Bldg
Building Alternate Address: 345 Park Ave South
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:12
Year Built:1912
Building Class:A

345 Park Avenue South, located in Midtown South, Manhattan, NYC, is a historic building originally completed in 1912 and designed by William H. Whittal. It was once known as the Armory Building.

The building underwent a full-scale renovation in 2021 by Deerfield, transforming it into a state-of-the-art office and life sciences hub known as CURE. This 12-story structure features lab-ready spaces, flexible office space, and a plethora of modern amenities. These include a rooftop terrace, lounge club, and fitness center, making it an attractive destination for life sciences, healthcare, and biotech companies.

Managed by RFR Realty and owned by Deerfield, 345 Park Avenue South offers approximately 300,000 square feet of office space. It is strategically located near the Flatiron District and Madison Square Park, with easy access to public transportation and upscale amenities.

345 Park Avenue South is located in the heart of Silicon Alley, Manhattan, providing a vibrant hub for innovation in the life sciences, digital health, and technology sectors.

This location is home to a premier life science facility, offering state-of-the-art lab spaces, ample amenities, and a collaborative community of leading companies. The building hosts a range of tenants involved in healthcare and biotech industries.

Originally built in 1912, the property was transformed into a Class A office and life sciences hub through a major renovation in 2021. It features 300,000 square feet of space across its 12 floors, including flexible office areas and ground-floor retail.

The area offers excellent connectivity, with easy access to major public transportation options and proximity to Madison Square Park.

Contact information for general inquiries about the building can be directed to its location at 345 Park Ave S, New York, NY 10010.


345 Park Avenue South in Manhattan offers a range of amenities:

  • Rooftop terrace with flexible event space and stunning views of Manhattan.
  • Lounge club and kitchen.
  • Renovated lobby.
  • Fitness center (available at an additional cost).
  • Exclusive wine cellar.
  • State-of-the-art conference center.
  • Conference rooms and huddle spaces.
  • NaCl Café on the 12th floor.
  • 2nd floor Education Center.


345 Park Avenue South in Manhattan, NYC, is home to several notable tenants. The building, part of Deerfield's CURE. life sciences hub, hosts tenants such as:

  • Deerfield
  • ProTara Therapeutics
  • Test Now and Go
  • Bank of America Financial Center
  • Helaina

Additionally, the Upland restaurant is located on the ground floor.


345 Park Avenue South, located in the heart of Manhattan, offers a prime spot for businesses and residents seeking reliable internet services. The area is covered by several top-tier internet providers, ensuring fast and consistent connectivity. Here are some of the internet providers likely available in the building:

Providers and Services:

  • Verizon Fios: Known for its fiber-optic connections, offering speeds up to 2 Gbps and competitive pricing.
  • Optimum: Offers high-speed plans up to 8 Gbps, ideal for demanding users.
  • Astound Broadband Powered by RCN: Provides affordable high-speed plans with unlimited data and fiber-optic connections.
  • Spectrum: Offers cable internet with speeds up to 1 Gbps and no data caps.

345 Park Avenue South, located in the heart of Midtown South, Manhattan, offers convenient access to multiple transportation options. The nearest subway stations include 28th Street, 23rd Street, and 33rd Street, with the 28th Street station being a 4-minute walk away. Bus stops are also nearby, including those on East 23rd Street and Madison Avenue, which is a 5-minute walk. The cross streets are Park Avenue South and Lexington Avenue, providing easy access to various amenities, restaurants, and parks in the area.


TPG Rewards Testimonial

TPG Rewards testimonial

We love a challenge!

Optimal Spaces can help you turn critical and complex real estate issues into opportunities for growth and or cost reduction. We offer the experience, know-how, and the strategic planning that helps lead to better decisions. Virtually everything you need to enhance the value of your business (for profit and not for profit) , you will find at Optimal Spaces.

About Optimal Spaces
Optimal Spaces are Tenant Brokers, only representing commercial tenants, not owners or landlords. By contrast, managing agents and most commercial brokers are "landlord agents" representing the interest of owners. Their goal is to market and lease their clients' properties with the best possible terms for the owners. Thus, they will neither show you as broad a selection nor push to get the best price, since their loyalty is to the Landlord. An Optimal Spaces agent will show you a broader range of properties and offer you a broader range of important services than a managing agent or commercial broker will. We will provide you with a market survey, floor plans, pricing expectations , and access to our rolodex: Optimal Spaces walks you through the process from start to finish. Upon entering your new space, it will look the way you want, all at the price you agreed to spend. In addition to negotiating the best price, we will reveal and abate many "hidden costs" to you. We will show you all the relevant available spaces and safeguard your interests throughout the process. Because of tour costs to provide these services, we ask in exchange that clients sign an Exclusive Brokerage Agreement. This allows us to plan appropriately for assisting you with every step of the process.

Find My Space!