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Rent/Lease Office 345 Park Avenue South

Lease Office 345 Park Avenue South

Rent Sublease Office at 345 Park Avenue South

Nearby Sublease office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 59
10,500
$ 51,625
Park Ave S & Between East 19th Street $ 60
7,700
$ 38,500
Fifth Ave & East 21st Street $ 69
7,300
$ 41,975
Fifth Ave & East 19th Street $ 77
8,800
$ 56,466
Fifth Ave & East 16th Street $ 42
10,100
$ 35,350
Address $ / SF SF Monthly Rent
Fifth Ave & East 21st Street $ 71
5,200
$ 30,766
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
E 16th St & Park Avenue South $ 64
3,400
$ 18,275
Address $ / SF SF Monthly Rent
Tipo de espacio Clase A/mes Clase B/mes Clase C/mes
Oficina con ventana/persona
Oficina interior/persona
Salas de equipo
Suites

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 92
9,100
$ 69,766
Park Ave S & East 20th Street $ 81
13,000
$ 87,750
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street $ 95
4,000
$ 31,666
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 61
8,300
$ 42,191
E 23rd St & Park Avenue $ 42
18,400
$ 64,400
Broadway & East 20th Street $ 70
18,200
$ 106,925
Park Ave S & Between East 19th Street $ 67
7,700
$ 42,991
Park Ave S & East 27th Street $ 75
8,700
$ 54,375
Fifth Ave & East 29th Street $ 79
12,500
$ 82,291
Park Ave S & East 27th Street $ 91
23,800
$ 180,483
Park Ave S & East 27th Street $ 70
13,100
$ 75,870
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Park Ave S & East 26th Street $ 48
12,000
$ 48,500
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 76
5,300
$ 33,787
E 23rd St & Park Avenue $ 41
6,100
$ 20,841
Broadway & East 20th Street $ 75
3,700
$ 23,125
Fifth Ave & East 29th Street $ 72
4,700
$ 28,200
Park Ave S & East 26th Street $ 71
3,900
$ 23,075
Park Ave S & East 26th Street $ 75
2,700
$ 16,875
University Pl & East 12th Street $ 49
6,500
$ 26,541
Broadway & East 18th Street $ 72
2,500
$ 14,895
Union Sq W & East 16th Street $ 67
3,700
$ 20,658
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 75
2,200
$ 13,750
E 23rd St & Third Avenue $ 46
2,400
$ 9,100
Park Ave S & East 26th Street $ 63
2,100
$ 11,025
Fifth Ave & East 29th Street $ 73
2,000
$ 12,100
Broadway & East 18th Street $ 74
1,800
$ 11,025
Address $ / SF SF Monthly Rent
E 19th St & Broadway $ 52
7,700
$ 33,687
Madison Ave & East 30th Street $ 40
11,000
$ 36,208
E 23rd St & Lexington Avenue $ 68
21,600
$ 121,500
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway $ 54
5,500
$ 24,520
Fifth Ave & East 29th Street $ 58
2,500
$ 12,083
Fifth Ave & Between East 28th Street $ 52
5,000
$ 21,458
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 38
2,300
$ 7,379
Broadway & East 21st Street $ 74
1,800
$ 11,175

Retail Spaces for Rent at 345 Park Avenue South

Office Tenants Rented / Leased 345 Park Avenue South
  • Digitas leased 240,000 SF
Retail Tenants Rented / Leased 345 Park Avenue South
  • Doral Bank leased 7,675 SF
Nearby Office Tenants Leased
  • Elizabeth Arden leased 35,698 SF at 200 Park Avenue South
  • Left/Right leased 34,000 SF at 39 West 19th Street
  • The Atlantic leased 33,609 SF at 60 Madison Ave
  • Enigma Technologies, Inc. leased 33,406 SF at 245 Fifth Ave
  • Work Better leased 33,103 SF at 33 West 19th St
  • The Yard leased 33,000 SF at 246 Fifth Avenue
  • Looker Data Sciences, Inc. leased 33,000 SF at 40 West 25th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S
Nearby Retail Tenants Leased
  • Free People leased 6,000 SF at 79 Fifth Ave
  • Duane Reade leased 6,000 SF at 184 Fifth Ave
  • Theory leased 5,500 SF at 139 Fifth Ave
  • Silk Trading leased 5,400 SF at 936 Broadway
  • Philippe Massoud restaurant leased 5,000 SF at 236 Fifth Ave
  • Kellogg's NYC leased 5,000 SF at 31 East 17th Street
  • Straussie's leased 4,954 SF at 41 Madison Avenue
  • New York Community Bank leased 4,811 SF at 404 Park Ave South
  • Schnipper's Quality Kitchen leased 4,790 SF at One Madison Ave
  • Thursday Boots leased 4,300 SF at 48 West 21st Street
$ / SF SF Monthly Rent
Please notify me when a new space is available
Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 345 Park Avenue South. This trend is projected to continue. Opportunities for subleases remain available at 345 Park Avenue South and in the nearby Gramercy Park neighborhood.
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345 Park Avenue South nyc
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345 Park Avenue South Property Overview

Building Address: 345 Park Avenue South, New York NY 10010
Building Name: The Iselin Bldg
Building Alternate Address: 345 Park Ave South
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:12
Year Built:1912
Building Class:A

345 Park Avenue South, located in Midtown South, Manhattan, NYC, is a historic building originally completed in 1912 and designed by William H. Whittal. It was once known as the Armory Building.

The building underwent a full-scale renovation in 2021 by Deerfield, transforming it into a state-of-the-art office and life sciences hub known as CURE. This 12-story structure features lab-ready spaces, flexible office space, and a plethora of modern amenities. These include a rooftop terrace, lounge club, and fitness center, making it an attractive destination for life sciences, healthcare, and biotech companies.

Managed by RFR Realty and owned by Deerfield, 345 Park Avenue South offers approximately 300,000 square feet of office space. It is strategically located near the Flatiron District and Madison Square Park, with easy access to public transportation and upscale amenities.

345 Park Avenue South is located in the heart of Silicon Alley, Manhattan, providing a vibrant hub for innovation in the life sciences, digital health, and technology sectors.

This location is home to a premier life science facility, offering state-of-the-art lab spaces, ample amenities, and a collaborative community of leading companies. The building hosts a range of tenants involved in healthcare and biotech industries.

Originally built in 1912, the property was transformed into a Class A office and life sciences hub through a major renovation in 2021. It features 300,000 square feet of space across its 12 floors, including flexible office areas and ground-floor retail.

The area offers excellent connectivity, with easy access to major public transportation options and proximity to Madison Square Park.

Contact information for general inquiries about the building can be directed to its location at 345 Park Ave S, New York, NY 10010.


345 Park Avenue South in Manhattan offers a range of amenities:

  • Rooftop terrace with flexible event space and stunning views of Manhattan.
  • Lounge club and kitchen.
  • Renovated lobby.
  • Fitness center (available at an additional cost).
  • Exclusive wine cellar.
  • State-of-the-art conference center.
  • Conference rooms and huddle spaces.
  • NaCl Café on the 12th floor.
  • 2nd floor Education Center.


345 Park Avenue South in Manhattan, NYC, is home to several notable tenants. The building, part of Deerfield's CURE. life sciences hub, hosts tenants such as:

  • Deerfield
  • ProTara Therapeutics
  • Test Now and Go
  • Bank of America Financial Center
  • Helaina

Additionally, the Upland restaurant is located on the ground floor.


345 Park Avenue South, located in the heart of Manhattan, offers a prime spot for businesses and residents seeking reliable internet services. The area is covered by several top-tier internet providers, ensuring fast and consistent connectivity. Here are some of the internet providers likely available in the building:

Providers and Services:

  • Verizon Fios: Known for its fiber-optic connections, offering speeds up to 2 Gbps and competitive pricing.
  • Optimum: Offers high-speed plans up to 8 Gbps, ideal for demanding users.
  • Astound Broadband Powered by RCN: Provides affordable high-speed plans with unlimited data and fiber-optic connections.
  • Spectrum: Offers cable internet with speeds up to 1 Gbps and no data caps.

345 Park Avenue South, located in the heart of Midtown South, Manhattan, offers convenient access to multiple transportation options. The nearest subway stations include 28th Street, 23rd Street, and 33rd Street, with the 28th Street station being a 4-minute walk away. Bus stops are also nearby, including those on East 23rd Street and Madison Avenue, which is a 5-minute walk. The cross streets are Park Avenue South and Lexington Avenue, providing easy access to various amenities, restaurants, and parks in the area.

Office Tenants Rented / Leased 345 Park Avenue South
  • Digitas leased 240,000 SF

Retail Tenants Rented / Leased 345 Park Avenue South
  • Doral Bank leased 7,675 SF
Nearby Office Tenants Leased
  • Elizabeth Arden leased 35,698 SF at 200 Park Avenue South
  • Left/Right leased 34,000 SF at 39 West 19th Street
  • The Atlantic leased 33,609 SF at 60 Madison Ave
  • Enigma Technologies, Inc. leased 33,406 SF at 245 Fifth Ave
  • Work Better leased 33,103 SF at 33 West 19th St
  • The Yard leased 33,000 SF at 246 Fifth Avenue
  • Looker Data Sciences, Inc. leased 33,000 SF at 40 West 25th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S

Nearby Retail Tenants Leased
  • Free People leased 6,000 SF at 79 Fifth Ave
  • Duane Reade leased 6,000 SF at 184 Fifth Ave
  • Theory leased 5,500 SF at 139 Fifth Ave
  • Silk Trading leased 5,400 SF at 936 Broadway
  • Philippe Massoud restaurant leased 5,000 SF at 236 Fifth Ave
  • Kellogg's NYC leased 5,000 SF at 31 East 17th Street
  • Straussie's leased 4,954 SF at 41 Madison Avenue
  • New York Community Bank leased 4,811 SF at 404 Park Ave South
  • Schnipper's Quality Kitchen leased 4,790 SF at One Madison Ave
  • Thursday Boots leased 4,300 SF at 48 West 21st Street
Office Tenants Rented / Leased 345 Park Avenue South
  • Digitas leased 240,000 SF
Retail Tenants Rented / Leased 345 Park Avenue South
  • Doral Bank leased 7,675 SF
Nearby Office Tenants Leased
  • Elizabeth Arden leased 35,698 SF at 200 Park Avenue South
  • Left/Right leased 34,000 SF at 39 West 19th Street
  • The Atlantic leased 33,609 SF at 60 Madison Ave
  • Enigma Technologies, Inc. leased 33,406 SF at 245 Fifth Ave
  • Work Better leased 33,103 SF at 33 West 19th St
  • The Yard leased 33,000 SF at 246 Fifth Avenue
  • Looker Data Sciences, Inc. leased 33,000 SF at 40 West 25th St
  • LinkShare Corporation leased 33,000 SF at 215 Park Ave S
  • Petco leased 29,989 SF at 860 Broadway
  • Progressive Plan Administrators Inc. leased 29,291 SF at 470 Park Ave S
Nearby Retail Tenants Leased
  • Free People leased 6,000 SF at 79 Fifth Ave
  • Duane Reade leased 6,000 SF at 184 Fifth Ave
  • Theory leased 5,500 SF at 139 Fifth Ave
  • Silk Trading leased 5,400 SF at 936 Broadway
  • Philippe Massoud restaurant leased 5,000 SF at 236 Fifth Ave
  • Kellogg's NYC leased 5,000 SF at 31 East 17th Street
  • Straussie's leased 4,954 SF at 41 Madison Avenue
  • New York Community Bank leased 4,811 SF at 404 Park Ave South
  • Schnipper's Quality Kitchen leased 4,790 SF at One Madison Ave
  • Thursday Boots leased 4,300 SF at 48 West 21st Street

Belzberg Technologies Inc Testimonial

Belzberg Technologies Inc testimonial To Whom It May Concern, Stephen Sunderland and the team at Optimal Spaces Inc. Inc. have handled a number of transactions for Belzberg Technologies in New York, Philadelphia, and Chicago. In New York alone, Optimal Spaces Inc. recently saved us almost a million dollars by finding a fully built data facility when we were about to build one. The team at Optimal Spaces Inc. was personable, hardworking, trustworthy and was able to both quickly and effectively determine our needs and find the appropriate solution. Belzberg Technologies continues to use Optimal Spaces Inc. for all its real estate needs and I would highly recommend their services to anyone attempting to navigate the commercial real estate market in New York. Please feel free to contact me at (212) 943-1400 Sydney Belzberg Chairman Belzberg Technologies (USA) Inc.
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Why Optimal Spaces –
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  • No fee for clients renting space.
  • We work for YOU, not the landlord.
  • Save 15–20% on your business costs.
  • Save 100–200 hours of research.
  • Access to all available spaces.
  • Specialized real estate expertise.

Alone or with other broker

  • Miss deals and hard-to-find spaces.
  • Potential conflict of interest (often represent landlords).
  • Only 10% of available spaces are online.
  • Lack of specialized expertise.
  • May not get the best terms or uncover hidden costs.
Why Use a Tenant Broker: Your Advocate in Commercial Real Estate
1. The Crucial Distinction: Whose Side Are They On?
2. It Almost Always Costs You Nothing
3. Access to “Hidden” Inventory
4. Negotiating Beyond Base Rent
5. Time Savings & Process Management
6. Mitigating Risk (the “Gotchas”)
Summary: Don’t rely on the landlord’s agent. A tenant broker is your advocate, provides better data, negotiates a complete package, and typically costs you nothing.
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