Expert Tenant Broker "No Fee"
We represent you, not the landlord

Rent/Lease Office 345 Park Avenue South

Lease Office 345 Park Avenue South

$ / SF SF Monthly Rent
Negotiable

Rent Sublease Office at 345 Park Avenue South

Nearby Sublease office Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 60
10,500
$ 52,062
Park Ave S & Between East 19th Street $ 60
7,700
$ 38,500
Fifth Ave & East 19th Street $ 77
8,800
$ 56,466
Fifth Ave & East 16th Street $ 42
10,100
$ 35,350
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Type of Space Class A/month Class B/month Class C/month
Windowed office/person
Interior office/person
Team Rooms
Suites

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street $ 92
9,100
$ 69,766
Park Ave S & East 20th Street $ 82
13,000
$ 88,291
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street $ 96
4,000
$ 31,833
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Avenue $ 62
8,300
$ 42,537
E 23rd St & Park Avenue $ 42
18,400
$ 65,166
Broadway & East 20th Street $ 71
18,200
$ 107,683
Park Ave S & Between East 19th Street $ 68
7,700
$ 43,312
Park Ave S & East 27th Street $ 75
8,700
$ 54,375
Fifth Ave & East 29th Street $ 80
12,500
$ 82,812
Park Ave S & East 27th Street $ 92
23,800
$ 181,475
Park Ave S & East 27th Street $ 70
13,100
$ 76,416
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Park Ave S & East 26th Street $ 49
12,000
$ 49,000
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 77
5,300
$ 34,008
E 23rd St & Park Avenue $ 42
6,100
$ 21,350
Broadway & East 20th Street $ 76
3,700
$ 23,433
Fifth Ave & East 29th Street $ 73
4,700
$ 28,591
Park Ave S & East 26th Street $ 72
3,900
$ 23,237
Park Ave S & East 26th Street $ 75
2,700
$ 16,875
University Pl & East 12th Street $ 50
6,500
$ 27,083
Broadway & East 18th Street $ 72
2,500
$ 15,104
Union Sq W & East 16th Street $ 65
3,700
$ 20,041
Address $ / SF SF Monthly Rent
Broadway & Between East 19th Street $ 76
2,200
$ 13,841
E 23rd St & Third Avenue $ 44
2,400
$ 8,700
Park Ave S & East 26th Street $ 61
2,100
$ 10,675
Fifth Ave & East 29th Street $ 71
2,000
$ 11,766
Broadway & East 18th Street $ 72
1,800
$ 10,725
Address $ / SF SF Monthly Rent
E 19th St & Broadway $ 53
7,700
$ 34,008
Madison Ave & East 30th Street $ 40
11,000
$ 36,666
E 23rd St & Lexington Avenue $ 68
21,600
$ 122,400
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway $ 54
5,500
$ 24,979
Fifth Ave & East 29th Street $ 59
2,500
$ 12,291
Fifth Ave & Between East 28th Street $ 52
5,000
$ 21,875
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 36
2,300
$ 6,995
Broadway & East 21st Street $ 72
1,800
$ 10,875

Retail Spaces for Rent at 345 Park Avenue South

$ / SF SF Monthly Rent
Please notify me when a new space is available
Tenant Broker’s Perspective: Return-to-office mandates are driving up rental prices at 345 Park Avenue South. This trend is projected to continue. Opportunities for subleases remain available at 345 Park Avenue South and in the nearby Gramercy Park neighborhood.
Find My Space!
345 Park Avenue South nyc
Thank you! we will be in touch.

Before you go please fill:



Search all rental options at 345 Park Avenue South

345 Park Avenue South Property Overview

Building Address: 345 Park Avenue South, New York NY 10010
Building Name: The Iselin Bldg
Building Alternate Address: 345 Park Ave South
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:12
Year Built:1912
Building Class:A

345 Park Avenue South, located in Midtown South, Manhattan, NYC, is a historic building originally completed in 1912 and designed by William H. Whittal. It was once known as the Armory Building.

The building underwent a full-scale renovation in 2021 by Deerfield, transforming it into a state-of-the-art office and life sciences hub known as CURE. This 12-story structure features lab-ready spaces, flexible office space, and a plethora of modern amenities. These include a rooftop terrace, lounge club, and fitness center, making it an attractive destination for life sciences, healthcare, and biotech companies.

Managed by RFR Realty and owned by Deerfield, 345 Park Avenue South offers approximately 300,000 square feet of office space. It is strategically located near the Flatiron District and Madison Square Park, with easy access to public transportation and upscale amenities.

345 Park Avenue South is located in the heart of Silicon Alley, Manhattan, providing a vibrant hub for innovation in the life sciences, digital health, and technology sectors.

This location is home to a premier life science facility, offering state-of-the-art lab spaces, ample amenities, and a collaborative community of leading companies. The building hosts a range of tenants involved in healthcare and biotech industries.

Originally built in 1912, the property was transformed into a Class A office and life sciences hub through a major renovation in 2021. It features 300,000 square feet of space across its 12 floors, including flexible office areas and ground-floor retail.

The area offers excellent connectivity, with easy access to major public transportation options and proximity to Madison Square Park.

Contact information for general inquiries about the building can be directed to its location at 345 Park Ave S, New York, NY 10010.


345 Park Avenue South in Manhattan offers a range of amenities:

  • Rooftop terrace with flexible event space and stunning views of Manhattan.
  • Lounge club and kitchen.
  • Renovated lobby.
  • Fitness center (available at an additional cost).
  • Exclusive wine cellar.
  • State-of-the-art conference center.
  • Conference rooms and huddle spaces.
  • NaCl Café on the 12th floor.
  • 2nd floor Education Center.


345 Park Avenue South in Manhattan, NYC, is home to several notable tenants. The building, part of Deerfield's CURE. life sciences hub, hosts tenants such as:

  • Deerfield
  • ProTara Therapeutics
  • Test Now and Go
  • Bank of America Financial Center
  • Helaina

Additionally, the Upland restaurant is located on the ground floor.


345 Park Avenue South, located in the heart of Manhattan, offers a prime spot for businesses and residents seeking reliable internet services. The area is covered by several top-tier internet providers, ensuring fast and consistent connectivity. Here are some of the internet providers likely available in the building:

Providers and Services:

  • Verizon Fios: Known for its fiber-optic connections, offering speeds up to 2 Gbps and competitive pricing.
  • Optimum: Offers high-speed plans up to 8 Gbps, ideal for demanding users.
  • Astound Broadband Powered by RCN: Provides affordable high-speed plans with unlimited data and fiber-optic connections.
  • Spectrum: Offers cable internet with speeds up to 1 Gbps and no data caps.

345 Park Avenue South, located in the heart of Midtown South, Manhattan, offers convenient access to multiple transportation options. The nearest subway stations include 28th Street, 23rd Street, and 33rd Street, with the 28th Street station being a 4-minute walk away. Bus stops are also nearby, including those on East 23rd Street and Madison Avenue, which is a 5-minute walk. The cross streets are Park Avenue South and Lexington Avenue, providing easy access to various amenities, restaurants, and parks in the area.


Double Agent Testimonial

Double Agent testimonial To Whom it May Concern: This is to give reference for Stephen Sunderland, who provided commercial real estate brokerage services to our firm, Double Agent. His work led to our signing of a five year lease and five year optional extension on 6,200 square feet of SOHO office space at a very competitive rate. I was extremely impressed by Stephen's professionalism and follow-through in helping us not only locate this space but also in bringing it to closing. He showed a good knowledge of our needs and through that avoided wasting our time showing us unsuitable properties. I would be glad to provide further reference for Stephen and you may feel free to call me about him. I can give him an unqualified recommendation. Best regards, Andrew Szabo Chairman and CEO Double Agent, Inc.
🤝
Tenant Representation: Optimal Spaces acts exclusively as a "Tenant Broker," only representing tenants, never landlords.
⚖️
Unbiased Service: Avoiding conflicts of interest, they provide impartial service, showing a wider range of properties and negotiating the best price.
🗂️
Comprehensive Process: Agents guide clients end-to-end, offering market surveys, floor plans, pricing expectations, and industry contacts.
🐷
Cost Savings: They negotiate rental price and identify/abate "hidden costs."

Why Optimal Spaces –
Tenant Broker

  • No fee for clients renting space.
  • We work for YOU, not the landlord.
  • Save 15–20% on your business costs.
  • Save 100–200 hours of research.
  • Access to all available spaces.
  • Specialized real estate expertise.

Alone or with other broker

  • Miss deals and hard-to-find spaces.
  • Potential conflict of interest (often represent landlords).
  • Only 10% of available spaces are online.
  • Lack of specialized expertise.
  • May not get the best terms or uncover hidden costs.
Why Use a Tenant Broker: Your Advocate in Commercial Real Estate
1. The Crucial Distinction: Whose Side Are They On?
2. It Almost Always Costs You Nothing
3. Access to “Hidden” Inventory
4. Negotiating Beyond Base Rent
5. Time Savings & Process Management
6. Mitigating Risk (the “Gotchas”)
Summary: Don’t rely on the landlord’s agent. A tenant broker is your advocate, provides better data, negotiates a complete package, and typically costs you nothing.

Office Buildings by Class in Gramercy Park

Find My Space!