Rent Office 380 Second Avenue

Lease Office - 380 Second Ave

$ / SF SF Monthly Rent
Please notify me when a new space is available
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent

Rent Sublease Office - 380 Second Ave

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
Rent Coworking Office
Type of Space Class A/month Class B/month Class C/month
Windowed office/person $ 2100 $ 2075 $ 775
Interior office/person $ 1350 $ 1575 $ 525
Team Rooms $ 10100 $ 8825 $ 5025
Suites $ 20100 $ 12825 $ 7025

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street Negotiable
7,100
Negotiable
Madison Ave & East 25th Street Negotiable
13,900
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
3,400
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
2,000
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 18th Street Negotiable
17,300
Negotiable
Madison Ave & East 29th Avenue $ 64
8,300
$ 43,920
Fifth Ave & East 19th Street Negotiable
21,700
Negotiable
Broadway & East 20th Street Negotiable
18,200
Negotiable
Madison Ave & East 26th Street Negotiable
17,200
Negotiable
Park Ave S & Between East 19th Street $ 70
7,700
$ 44,595
Park Ave S & East 27th Street Negotiable
8,700
Negotiable
Fifth Ave & East 17th Street Negotiable
7,100
Negotiable
Union Sq W & East 16th Street Negotiable
9,200
Negotiable
Fifth Ave & East 29th Street Negotiable
12,500
Negotiable
Park Ave S & brian Negotiable
21,100
Negotiable
Park Ave S & East 27th Street Negotiable
19,300
Negotiable
E 29th St & Madison Avenue Negotiable
7,000
Negotiable
Park Ave S & East 27th Street Negotiable
11,600
Negotiable
Madison Ave & East 30th Street Negotiable
8,200
Negotiable
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Fifth Ave & East 16th Street Negotiable
9,100
Negotiable
Address $ / SF SF Monthly Rent
Union Sq W & Broadway Negotiable
3,800
Negotiable
Park Ave S & East 18th Street Negotiable
2,900
Negotiable
Broadway & Between East 19th Street Negotiable
3,600
Negotiable
Broadway & East 20th Street Negotiable
3,700
Negotiable
Park Ave S & East 17th Street Negotiable
2,500
Negotiable
E 23rd St & Third Avenue Negotiable
3,300
Negotiable
E 17th St & Fifth Avenue Negotiable
3,000
Negotiable
Fifth Ave & East 29th Street $ 76
4,700
$ 29,766
Park Ave S & East 24th Street Negotiable
3,600
Negotiable
E 29th St & Madison Avenue Negotiable
6,700
Negotiable
Park Ave S & East 26th Street Negotiable
4,000
Negotiable
University Pl & East 12th Street Negotiable
6,500
Negotiable
Fifth Ave & East 27th Street Negotiable
6,500
Negotiable
E 21st St & Broadway Negotiable
5,200
Negotiable
Fifth Ave & East 29th Street Negotiable
2,700
Negotiable
Fifth Ave & East 21st Street Negotiable
5,500
Negotiable
Broadway & East 18th Street $ 76
2,500
$ 15,937
Union Sq E & East 17h Street Negotiable
4,400
Negotiable
Madison Ave & East 28th Street Negotiable
5,400
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 18th Street Negotiable
1,700
Negotiable
Broadway & Between East 19th Street Negotiable
2,500
Negotiable
Park Ave S & East 17th Street Negotiable
1,600
Negotiable
E 23rd St & Third Avenue $ 49
2,400
$ 9,800
Fifth Ave & East 12th Street Negotiable
2,400
Negotiable
Park Ave S & East 26th Street Negotiable
2,100
Negotiable
Park Ave S & East 26th Street Negotiable
1,600
Negotiable
E 20th St & Third Avenue Negotiable
2,100
Negotiable
Broadway & East 18th Street $ 77
1,800
$ 11,550
Address $ / SF SF Monthly Rent
E 16th St & Fifth Avenue Negotiable
7,800
Negotiable
Fifth Ave & East 15th Street Negotiable
20,100
Negotiable
E 30th St & Park Avenue South Negotiable
8,000
Negotiable
Madison Ave & East 30th Street $ 42
11,000
$ 38,500
E 23rd St & Lexington Avenue Negotiable
12,300
Negotiable
Address $ / SF SF Monthly Rent
E 16th St & Fifth Avenue Negotiable
3,300
Negotiable
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway Negotiable
5,500
Negotiable
Fifth Ave & East 29th Street Negotiable
3,000
Negotiable
Park Ave S & East 24th Street Negotiable
4,000
Negotiable
Fifth Ave & Between East 28th Street $ 56
5,000
$ 23,125
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 42
2,300
$ 8,050
E 23rd St & Broadway Negotiable
2,300
Negotiable
Broadway & East 21st Street $ 78
1,800
$ 11,700

Retail Spaces for Rent

Rent Retail - 380 Second Ave

$ / SF SF >Monthly Rent
$ / SF SF >Monthly Rent
$ / SF SF >Monthly Rent

Rent Retail - 380 Second Ave

$ / SF SF >Monthly Rent
$ / SF SF >Monthly Rent
$ / SF SF >Monthly Rent

Nearby retail Spaces for Rent

Address $ / SF SF Monthly Rent
First Ave & East 22nd Street $ 162
2,200
$ 29,749
Madison Ave & Between East 23rd Street Negotiable
4,300
Negotiable
Madison Ave & East 26th Street Negotiable
5,500
Negotiable
Madison Ave & East 28th Street Negotiable
6,200
Negotiable
Park Ave S & East 17th Street Negotiable
4,900
Negotiable
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
3,800
Negotiable
Fifth Ave & East 16th Street $ 53
9,700
$ 42,841
Union Sq W & East 14th Street Negotiable
4,600
Negotiable
E 23rd St & Lexington Avenue $ 125
11,600
$ 120,833
Park Ave S & East 23rd Street Negotiable
7,000
Negotiable
E 17th St & Park Avenue South Negotiable
4,500
Negotiable
Union Sq W & East 17th Street Negotiable
4,200
Negotiable
Union Sq W & Broadway Negotiable
2,800
Negotiable
Fifth Ave & Between East 17th Street Negotiable
2,500
Negotiable
E 26th St & Fifth Avenue Negotiable
5,600
Negotiable
Fifth Ave & East 21st Street Negotiable
5,500
Negotiable
E 23rd St & Third Avenue Negotiable
2,100
Negotiable
Union Sq E & East 15th Street Negotiable
9,900
Negotiable
Address $ / SF SF Monthly Rent
Gramercy Park S & East 19th Street Negotiable
1,800
Negotiable
E 23rd St & Third Avenue Negotiable
1,800
Negotiable
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 115
2,500
$ 23,958
Fifth Ave & Between East 28th Street Negotiable
4,000
Negotiable
E 19th St & Broadway $ 48
5,500
$ 22,000
Broadway & East 13th Street Negotiable
3,600
Negotiable
E 18th St & Broadway Negotiable
8,900
Negotiable
Union Sq W & East 16th Street Negotiable
8,300
Negotiable
Broadway & Between East 12th Street Negotiable
9,000
Negotiable
Broadway & East 21st Street Negotiable
3,000
Negotiable
E 23rd St & Lexington Avenue $ 126
11,600
$ 121,316
Address $ / SF SF Monthly Rent
Fifth Ave & Between East 28th Street Negotiable
1,600
Negotiable
E 23rd St & Broadway $ 180
1,500
$ 22,500
Address $ / SF SF Monthly Rent
Broadway & East 13th Street Negotiable
600
Negotiable

Rent Medical Space

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
Negotiable
2,400
Negotiable
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
Negotiable
1,300
Negotiable

Nearby medical Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Street Negotiable
7,800
Negotiable
E 23rd St & Park Avenue $ 40
6,100
$ 20,587
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Street Negotiable
3,600
Negotiable
E 23rd St & Park Avenue $ 40
3,000
$ 10,125
Address $ / SF SF Monthly Rent
Union Sq E & East 15th Street Negotiable
1,900
Negotiable
Park Ave S & East 26th Street Negotiable
2,600
Negotiable
Address $ / SF SF Monthly Rent
W 145th St & Between Broadway $ 36
9,500
$ 28,104
Address $ / SF SF Monthly Rent
Broadway & East 21st Street $ 60
4,100
$ 20,670
Address $ / SF SF Monthly Rent
W 145th St & Between Broadway $ 38
2,300
$ 7,379
Broadway & East 21st Street $ 58
1,600
$ 7,800
380 Second Avenue nyc
Thank you! we will be in touch.

Before you go please fill:


Lease 380 Second Avenue

Rent 380 Second Avenue Property Overview

Bulding Address: 380 Second Ave, New York NY 10010
Building Alternate address: 380 2nd Ave
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:10
Year Built:1909
Building Class:B
Block & lot:00927-0055

The Gramercy Medical Arts Building, located at 380 Second Avenue in Manhattan, NYC, has a rich history dating back to the early 20th century. Constructed in 1909, it is situated in the Gramercy Park neighborhood and stands as a significant example of the area's development and transformation over time.

Originally built as a general office building, it has undergone transformations to become a hub for medical and educational institutions. The building was recently rebranded as the Gramercy Medical Arts Building due to its prominent tenants in the healthcare, arts, and education sectors.

It features a total of 182,258 square feet, spread across 10 stories. The building includes notable facilities such as bio-tech/lab spaces and offers amenities like 24-hour access, security systems, and Wi-Fi.

Current tenants include renowned institutions like NYU Langone Health, the Hospital for Joint Diseases, New York University, and the School of Visual Arts, reflecting its strategic importance in "Medical/Education Alley."

380 Second Avenue, Manhattan, NYC is also known as the Gramercy Medical Arts Building. Located in the heart of "Medical/Education Alley," it serves as a hub for renowned medical and educational institutions. The building stands 10 stories tall, offering 198,000 square feet of Class B office space with 20,000 rentable square foot floor plates. It features amenities like 24-hour access, biotech/lab space, concierge service, on-site management, security, high ceilings, and tenant-controlled HVAC. The property includes two handicapped-accessible lobbies and a private loading dock on 22nd Street, making it ideal for healthcare-related businesses and medical practitioners. Notable tenants include NYU Langone Health, NYU's Department of Physical Therapy, Mt. Sinai's New York Eye & Ear Infirmary, and the School of Visual Arts.


Building Amenities at 380 Second Avenue, Manhattan, NYC

  • 24-hour access
  • Biotech/lab space
  • Concierge service
  • On-site property management and security
  • High ceilings
  • Tenant-controlled HVAC
  • 300-pound floor loads
  • Two handicapped-accessible lobbies
  • Private loading dock on 22nd Street
  • Medical office features including hardwood floors, good natural light, and north and west views along 2nd Avenue
  • Existing buildout with reception area, consultation room, exam rooms with sinks and built-in cabinetry, lab room, and private restroom
  • Long-term stable ownership with ongoing renovation and expansion of second lobby at 310 East 22nd Street

Office Tenants at 380 Second Avenue, Manhattan, NYC

380 Second Avenue is a prominent 10-story Class B office and medical building located in Manhattan’s Gramercy Park neighborhood. Known as the Gramercy Medical Arts Building, it hosts a prestigious roster of tenants primarily from healthcare, medical, and educational sectors.

  • Gramercy Surgery Center
  • NYU Langone Health
  • NYU’s Department of Physical Therapy and College of Dentistry
  • NYU Langone Hospital's Diagnostic Imaging Center
  • Hospital for Joint Diseases (NYU Langone)
  • Mt. Sinai’s New York Eye & Ear Infirmary
  • School of Visual Arts
  • MedRite
  • East Side Endoscopy
  • Gramercy Surgical Center

The building features amenities including tenant-controlled HVAC, 24-hour access, concierge service, on-site property management and security, high ceilings, biotech/lab space, and a private loading dock. The floors have a 300-pound load capacity and benefit from abundant natural light, with the upper floors offering views of the NYC skyline.


Internet Providers at 380 Second Ave, Manhattan, NYC:

Although specific providers at this location are not listed, typical internet providers in Manhattan include:

  • Verizon Fios: Known for high speeds and reliable fiber-optic service.
  • Astound Broadband Powered by RCN: Offers cable and fiber services with competitive pricing.
  • Spectrum: Provides widespread cable internet coverage across Manhattan.
  • Other Options: T-Mobile Home Internet and fixed wireless providers like STARRY may also be available.

For precise availability, contacting each provider directly is recommended.

380 Second Avenue is located in the heart of Manhattan's Gramercy Park neighborhood. It is easily accessible by public transportation.

Nearest Subway Stations: - 23rd Street (R, W trains) - 14th Street – Union Square (4, 5, 6, L, N, Q, W trains)

Bus Lines: - BM3, M101, M15-SBS, M23-SBS, M34A-SBS

Cross Streets: - First Avenue and Second Avenue

Public Transportation Directions: - To get there by subway, take the R or W train to 23rd Street and exit towards 2nd Avenue. - For bus, take any of the bus lines mentioned above and get off at the nearest stop to 2nd Avenue and 23rd Street.

Rent Office - 380 Second Avenue Average

Year $ / SF
2018 67.0
Year$ / SF

Abrams Garfinkel & Rosen Testimonial

Abrams Garfinkel & Rosen testimonial

We love a challenge!

Optimal Spaces can help you turn critical and complex real estate issues into opportunities for growth and or cost reduction. We offer the experience, know-how, and the strategic planning that helps lead to better decisions. Virtually everything you need to enhance the value of your business (for profit and not for profit) , you will find at Optimal Spaces.

About Optimal Spaces
Optimal Spaces are Tenant Brokers, only representing commercial tenants, not owners or landlords. By contrast, managing agents and most commercial brokers are "landlord agents" representing the interest of owners. Their goal is to market and lease their clients' properties with the best possible terms for the owners. Thus, they will neither show you as broad a selection nor push to get the best price, since their loyalty is to the Landlord. An Optimal Spaces agent will show you a broader range of properties and offer you a broader range of important services than a managing agent or commercial broker will. We will provide you with a market survey, floor plans, pricing expectations , and access to our rolodex: Optimal Spaces walks you through the process from start to finish. Upon entering your new space, it will look the way you want, all at the price you agreed to spend. In addition to negotiating the best price, we will reveal and abate many "hidden costs" to you. We will show you all the relevant available spaces and safeguard your interests throughout the process. Because of tour costs to provide these services, we ask in exchange that clients sign an Exclusive Brokerage Agreement. This allows us to plan appropriately for assisting you with every step of the process.

Buildings Offices in Gramercy Park

Find My Space!

join our mailing list

Thank you! we will be in touch.
Please enter a valid email address is required. Your email is required to be at least 3 characters That is not a valid email. Please input a valid email. Your email cannot be longer than 20 characters
Please enter a valid email address is required.