Rent Retail 540-580 Main Street

History of 540-580 Main Street, Manhattan, NYC

The buildings at 540-580 Main Street are located on Roosevelt Island, a unique neighborhood in Manhattan situated in the East River. Roosevelt Island has a rich history, having been known as Welfare Island for much of its past. It served primarily as a site for several hospitals before large-scale redevelopment began in 1969.

The redevelopment involved the construction of residential apartment towers designed by noted architects. The site at 540-580 Main Street comprises low-rise commercial structures and retail spaces known as the Roosevelt Island Shops on Main, built in 1975. These buildings stand as part of the island’s broader transformation into a residential and mixed-use community.

Roosevelt Island itself is notable for its geographic distinctiveness—it is accessible from Manhattan only by the Roosevelt Island Tramway or the F train subway line, while from Queens it can be reached by car or bus via the Roosevelt Island Bridge or ferry services. This isolation gives the island and its buildings, including those on Main Street, a character of their own within New York City.

540-580 Main Street features ground-floor retail space and commercial offices primarily serving the local Roosevelt Island community. The building is classified as a Class B property, is two stories tall, and reflects the modern urban development efforts on the island since the mid-20th century.

Office Tenants Rented / Leased at 540-580 Main Street, Manhattan, NYC

540-580 Main Street, also known as Roosevelt Island Shops on Main, is a commercial building in the Upper East Side neighborhood of Manhattan, New York. The building offers office and retail spaces suitable for medical and other professional uses.

Available Office Space Details

Featured Office / Medical Space at 520 Main Street

Located near 540-580 Main Street, this furnished office medical space includes a 3,835 square foot unit with nine exam rooms, X-ray room, lab, treatment and conference rooms, two private offices, reception area, kitchen, and three restrooms. The space is wheelchair accessible and in excellent condition with 33 feet of frontage along Main Street.

• Fully built-out standard medical space
• Reception area and kitchen included
• Good transportation access to Manhattan and Queens
• Located close to Cornell Tech Roosevelt Island campus

Lease term and rental rate: Negotiable upon request.