Rent Office 345 Park Avenue South

Lease Office - The Iselin Bldg

$ / SF SF Monthly Rent
Negotiable
11,600
Negotiable
Please notify me when a new space is available
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent

Rent Sublease Office - 345 Park Avenue South

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
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Rent Coworking Office
Type of Space Class A/month Class B/month Class C/month
Windowed office/person $ 2597 $ 1300 $ 775
Interior office/person $ 1847 $ 800 $ 525
Team Rooms $ 10597 $ 8050 $ 5025
Suites $ 20597 $ 12050 $ 7025

Nearby office Spaces for Rent

Address $ / SF SF Monthly Rent
Madison Ave & East 25th Street Negotiable
7,100
Negotiable
Madison Ave & East 25th Street Negotiable
13,900
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
3,400
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
2,000
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 18th Street Negotiable
17,300
Negotiable
Madison Ave & East 29th Avenue $ 64
8,300
$ 43,920
Fifth Ave & East 19th Street Negotiable
21,700
Negotiable
Broadway & East 20th Street Negotiable
18,200
Negotiable
Madison Ave & East 26th Street Negotiable
17,200
Negotiable
Park Ave S & Between East 19th Street $ 70
7,700
$ 44,595
Park Ave S & East 27th Street Negotiable
8,700
Negotiable
Fifth Ave & East 17th Street Negotiable
7,100
Negotiable
Union Sq W & East 16th Street Negotiable
9,200
Negotiable
Fifth Ave & East 29th Street Negotiable
12,500
Negotiable
Park Ave S & brian Negotiable
21,100
Negotiable
Park Ave S & East 27th Street Negotiable
19,300
Negotiable
E 29th St & Madison Avenue Negotiable
7,000
Negotiable
Park Ave S & East 27th Street Negotiable
11,600
Negotiable
Madison Ave & East 30th Street Negotiable
8,200
Negotiable
E 26th St & Fifth Avenue $ 125
12,100
$ 126,041
Fifth Ave & East 16th Street Negotiable
9,100
Negotiable
Address $ / SF SF Monthly Rent
Union Sq W & Broadway Negotiable
3,800
Negotiable
Park Ave S & East 18th Street Negotiable
2,900
Negotiable
Broadway & Between East 19th Street Negotiable
3,600
Negotiable
Broadway & East 20th Street Negotiable
3,700
Negotiable
Park Ave S & East 17th Street Negotiable
2,500
Negotiable
E 23rd St & Third Avenue Negotiable
3,300
Negotiable
E 17th St & Fifth Avenue Negotiable
3,000
Negotiable
Fifth Ave & East 29th Street $ 76
4,700
$ 29,766
Park Ave S & East 24th Street Negotiable
3,600
Negotiable
E 29th St & Madison Avenue Negotiable
6,700
Negotiable
Park Ave S & East 26th Street Negotiable
4,000
Negotiable
University Pl & East 12th Street Negotiable
6,500
Negotiable
Fifth Ave & East 27th Street Negotiable
6,500
Negotiable
E 21st St & Broadway Negotiable
5,200
Negotiable
Fifth Ave & East 29th Street Negotiable
2,700
Negotiable
Fifth Ave & East 21st Street Negotiable
5,500
Negotiable
Broadway & East 18th Street $ 76
2,500
$ 15,937
Union Sq E & East 17h Street Negotiable
4,400
Negotiable
Madison Ave & East 28th Street Negotiable
5,400
Negotiable
Address $ / SF SF Monthly Rent
Park Ave S & East 18th Street Negotiable
1,700
Negotiable
Broadway & Between East 19th Street Negotiable
2,500
Negotiable
Park Ave S & East 17th Street Negotiable
1,600
Negotiable
E 23rd St & Third Avenue $ 49
2,400
$ 9,800
Fifth Ave & East 12th Street Negotiable
2,400
Negotiable
Park Ave S & East 26th Street Negotiable
2,100
Negotiable
Park Ave S & East 26th Street Negotiable
1,600
Negotiable
E 20th St & Third Avenue Negotiable
2,100
Negotiable
Broadway & East 18th Street $ 77
1,800
$ 11,550
Address $ / SF SF Monthly Rent
E 16th St & Fifth Avenue Negotiable
7,800
Negotiable
Fifth Ave & East 15th Street Negotiable
20,100
Negotiable
E 30th St & Park Avenue South Negotiable
8,000
Negotiable
Madison Ave & East 30th Street $ 42
11,000
$ 38,500
E 23rd St & Lexington Avenue Negotiable
12,300
Negotiable
Address $ / SF SF Monthly Rent
E 16th St & Fifth Avenue Negotiable
3,300
Negotiable
E 23rd St & Park Avenue $ 35
2,800
$ 8,166
E 19th St & Broadway Negotiable
5,500
Negotiable
Fifth Ave & East 29th Street Negotiable
3,000
Negotiable
Park Ave S & East 24th Street Negotiable
4,000
Negotiable
Fifth Ave & Between East 28th Street $ 56
5,000
$ 23,125
Address $ / SF SF Monthly Rent
E 28th St & Park Avenue South $ 42
2,300
$ 8,050
E 23rd St & Broadway Negotiable
2,300
Negotiable
Broadway & East 21st Street $ 78
1,800
$ 11,700

Retail Spaces for Rent

Rent Retail - 345 Park Avenue South

$ / SF SF >Monthly Rent
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Rent Retail - 345 Park Avenue South

$ / SF SF >Monthly Rent
$ / SF SF >Monthly Rent
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Nearby retail Spaces for Rent

Address $ / SF SF Monthly Rent
First Ave & East 22nd Street $ 162
2,200
$ 29,749
Madison Ave & Between East 23rd Street Negotiable
4,300
Negotiable
Madison Ave & East 26th Street Negotiable
5,500
Negotiable
Madison Ave & East 28th Street Negotiable
6,200
Negotiable
Park Ave S & East 17th Street Negotiable
4,900
Negotiable
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Park Ave S & East 17th Street Negotiable
3,800
Negotiable
Fifth Ave & East 16th Street $ 53
9,700
$ 42,841
Union Sq W & East 14th Street Negotiable
4,600
Negotiable
E 23rd St & Lexington Avenue $ 125
11,600
$ 120,833
Park Ave S & East 23rd Street Negotiable
7,000
Negotiable
E 17th St & Park Avenue South Negotiable
4,500
Negotiable
Union Sq W & East 17th Street Negotiable
4,200
Negotiable
Union Sq W & Broadway Negotiable
2,800
Negotiable
Fifth Ave & Between East 17th Street Negotiable
2,500
Negotiable
E 26th St & Fifth Avenue Negotiable
5,600
Negotiable
Fifth Ave & East 21st Street Negotiable
5,500
Negotiable
E 23rd St & Third Avenue Negotiable
2,100
Negotiable
Union Sq E & East 15th Street Negotiable
9,900
Negotiable
Address $ / SF SF Monthly Rent
Gramercy Park S & East 19th Street Negotiable
1,800
Negotiable
E 23rd St & Third Avenue Negotiable
1,800
Negotiable
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
E 23rd St & Park Avenue $ 115
2,500
$ 23,958
Fifth Ave & Between East 28th Street Negotiable
4,000
Negotiable
E 19th St & Broadway $ 48
5,500
$ 22,000
Broadway & East 13th Street Negotiable
3,600
Negotiable
E 18th St & Broadway Negotiable
8,900
Negotiable
Union Sq W & East 16th Street Negotiable
8,300
Negotiable
Broadway & Between East 12th Street Negotiable
9,000
Negotiable
Broadway & East 21st Street Negotiable
3,000
Negotiable
E 23rd St & Lexington Avenue $ 126
11,600
$ 121,316
Address $ / SF SF Monthly Rent
Fifth Ave & Between East 28th Street Negotiable
1,600
Negotiable
E 23rd St & Broadway $ 180
1,500
$ 22,500
Address $ / SF SF Monthly Rent
Broadway & East 13th Street Negotiable
600
Negotiable

Rent Medical Space

$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent
$ / SF SF Monthly Rent

Nearby medical Spaces for Rent

Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Street Negotiable
7,800
Negotiable
E 23rd St & Park Avenue $ 40
6,100
$ 20,587
Address $ / SF SF Monthly Rent
Madison Ave & East 29th Street Negotiable
3,600
Negotiable
E 23rd St & Park Avenue $ 40
3,000
$ 10,125
Address $ / SF SF Monthly Rent
Union Sq E & East 15th Street Negotiable
1,900
Negotiable
Park Ave S & East 26th Street Negotiable
2,600
Negotiable
Second Ave & East 22nd Street Negotiable
2,400
Negotiable
Address $ / SF SF Monthly Rent
W 145th St & Between Broadway $ 36
9,500
$ 28,104
Address $ / SF SF Monthly Rent
Broadway & East 21st Street $ 60
4,100
$ 20,670
Address $ / SF SF Monthly Rent
W 145th St & Between Broadway $ 38
2,300
$ 7,379
Broadway & East 21st Street $ 58
1,600
$ 7,800
345 Park Avenue South nyc
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Lease 345 Park Avenue South

Rent 345 Park Avenue South Property Overview

Bulding Address: 345 Park Avenue South, New York NY 10010
Building Name: The Iselin Bldg
Building Alternate address: 345 Park Ave South
Zip Code:10010
Neighborhood:Gramercy Park
Borough:Manhattan
Stories:12
Year Built:1912
Building Class:A

345 Park Avenue South, located in Midtown South, Manhattan, NYC, is a historic building originally completed in 1912 and designed by William H. Whittal. It was once known as the Armory Building.

The building underwent a full-scale renovation in 2021 by Deerfield, transforming it into a state-of-the-art office and life sciences hub known as CURE. This 12-story structure features lab-ready spaces, flexible office space, and a plethora of modern amenities. These include a rooftop terrace, lounge club, and fitness center, making it an attractive destination for life sciences, healthcare, and biotech companies.

Managed by RFR Realty and owned by Deerfield, 345 Park Avenue South offers approximately 300,000 square feet of office space. It is strategically located near the Flatiron District and Madison Square Park, with easy access to public transportation and upscale amenities.

345 Park Avenue South is located in the heart of Silicon Alley, Manhattan, providing a vibrant hub for innovation in the life sciences, digital health, and technology sectors.

This location is home to a premier life science facility, offering state-of-the-art lab spaces, ample amenities, and a collaborative community of leading companies. The building hosts a range of tenants involved in healthcare and biotech industries.

Originally built in 1912, the property was transformed into a Class A office and life sciences hub through a major renovation in 2021. It features 300,000 square feet of space across its 12 floors, including flexible office areas and ground-floor retail.

The area offers excellent connectivity, with easy access to major public transportation options and proximity to Madison Square Park.

Contact information for general inquiries about the building can be directed to its location at 345 Park Ave S, New York, NY 10010.


345 Park Avenue South in Manhattan offers a range of amenities:

  • Rooftop terrace with flexible event space and stunning views of Manhattan.
  • Lounge club and kitchen.
  • Renovated lobby.
  • Fitness center (available at an additional cost).
  • Exclusive wine cellar.
  • State-of-the-art conference center.
  • Conference rooms and huddle spaces.
  • NaCl Café on the 12th floor.
  • 2nd floor Education Center.


345 Park Avenue South in Manhattan, NYC, is home to several notable tenants. The building, part of Deerfield's CURE. life sciences hub, hosts tenants such as:

  • Deerfield
  • ProTara Therapeutics
  • Test Now and Go
  • Bank of America Financial Center
  • Helaina

Additionally, the Upland restaurant is located on the ground floor.


345 Park Avenue South, located in the heart of Manhattan, offers a prime spot for businesses and residents seeking reliable internet services. The area is covered by several top-tier internet providers, ensuring fast and consistent connectivity. Here are some of the internet providers likely available in the building:

Providers and Services:

  • Verizon Fios: Known for its fiber-optic connections, offering speeds up to 2 Gbps and competitive pricing.
  • Optimum: Offers high-speed plans up to 8 Gbps, ideal for demanding users.
  • Astound Broadband Powered by RCN: Provides affordable high-speed plans with unlimited data and fiber-optic connections.
  • Spectrum: Offers cable internet with speeds up to 1 Gbps and no data caps.

345 Park Avenue South, located in the heart of Midtown South, Manhattan, offers convenient access to multiple transportation options. The nearest subway stations include 28th Street, 23rd Street, and 33rd Street, with the 28th Street station being a 4-minute walk away. Bus stops are also nearby, including those on East 23rd Street and Madison Avenue, which is a 5-minute walk. The cross streets are Park Avenue South and Lexington Avenue, providing easy access to various amenities, restaurants, and parks in the area.

Rent Office - 345 Park Avenue South Average

Year $ / SF
2018 62.0
2019 62.0
Year$ / SF

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Optimal Spaces can help you turn critical and complex real estate issues into opportunities for growth and or cost reduction. We offer the experience, know-how, and the strategic planning that helps lead to better decisions. Virtually everything you need to enhance the value of your business (for profit and not for profit) , you will find at Optimal Spaces.

About Optimal Spaces
Optimal Spaces are Tenant Brokers, only representing commercial tenants, not owners or landlords. By contrast, managing agents and most commercial brokers are "landlord agents" representing the interest of owners. Their goal is to market and lease their clients' properties with the best possible terms for the owners. Thus, they will neither show you as broad a selection nor push to get the best price, since their loyalty is to the Landlord. An Optimal Spaces agent will show you a broader range of properties and offer you a broader range of important services than a managing agent or commercial broker will. We will provide you with a market survey, floor plans, pricing expectations , and access to our rolodex: Optimal Spaces walks you through the process from start to finish. Upon entering your new space, it will look the way you want, all at the price you agreed to spend. In addition to negotiating the best price, we will reveal and abate many "hidden costs" to you. We will show you all the relevant available spaces and safeguard your interests throughout the process. Because of tour costs to provide these services, we ask in exchange that clients sign an Exclusive Brokerage Agreement. This allows us to plan appropriately for assisting you with every step of the process.

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