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SoHo Medical Office Listings
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| A | W Broadway & Prince Street Floor 2 (full) | 6,500 | $ Negotiable | |
| Small Medical Offices for Rent | ||||
| B | Canal St & Mott Street Floor 3 | 1,800 | $ 6,200 | |
| C | Elizabeth St & Mott Street Floor 6 | 1,200 | $ 3,600 | |
| Class | Address | SF | Monthly Rent | |
|---|---|---|---|---|
| Large Medical Offices for Rent | ||||
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 6,000 | $ 20,000 | |
| B | Fifth Ave & East 35th Street Penn Plaza/Garment · Floor 9 (full) | 5,300 | $ Negotiable | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 5,000 | $ 16,600 | |
| Medium Medical Offices for Rent | ||||
| B | Fifth Ave & East 35th Street Penn Plaza/Garment · Floor 9 (full) | 4,300 | $ Negotiable | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 4,000 | $ 13,200 | |
| B | Fifth Ave & East 35th Street Penn Plaza/Garment · Floor 9 (full) | 3,300 | $ Negotiable | |
| B | E 23rd Street & Park Avenue Gramercy Park · Floor 10 (full) | 3,000 | $ 10,000 | |
| Small Medical Offices for Rent | ||||
| B | Fifth Ave & East 35th Street Penn Plaza/Garment · Floor 9 (full) | 2,300 | $ Negotiable | |
| B | Mott St & Grand Street SoHo · Floor 3 | 1,700 | $ 9,800 | |
| B | Fifth Ave & East 35th Street Penn Plaza/Garment · Floor 9 (full) | 1,300 | $ Negotiable | |
Medical Tenants Rented / Leased SoHo
- Downtown Women OB/GYN Associates, LLP leased 8,084 SF at 568-578 Broadway
- Physiofitness Physical Therapy leased 7,472 SF at 584-590 Broadway
- Stephen Wan, MD, PLLC leased 5,072 SF at 213-217 Grand St
- Schweiger Dermatology Group LLC leased 3,500 SF at 598 Broadway
- New York Hearing Center Inc leased 2,800 SF at 128-138 Mott St
- Dr. George Hall, MD leased 2,500 SF at 213-217 Grand St
- Sapna Westley MD, PC leased 1,746 SF at 594 Broadway
- Optimum Care Physical Therapy leased 800 SF at 185 Canal St
- James G Rong, DDS leased 750 SF at 185 Canal St
Excellent opportunities for medical space still exist if you know where to look. Optimal Spaces has a proven track record of securing these spaces for our clients on the best possible terms.
We are dedicated tenant brokers, meaning we exclusively represent your interests, never the landlord’s.
Why choose Optimal Spaces?
- Significant Savings: We typically save clients 10–15% compared with what they could negotiate on their own.
- Time Efficiency: We eliminate 100–200 hours of blind, unnecessary research for you.
- No Conflict of Interest: We represent only you, not the landlord.
Optimal Spaces consistently delivers exceptional spaces and advantageous deals for our clients. See their success: New York Medical Office Testimonials .
Why Optimal Spaces Tenant Broker
- Lease negotiation: full terms, renewals, expansion options
- Cost analysis, inventory identification, negotiating scope
- Risk mitigation against hidden pitfalls
Cost Savings
- Negotiate 30+ leasing points to prevent hidden costs
- Save 10–15% on total leasing costs
- Save 100–200 hours filtering unviable spaces
- Property access via broker databases and networks (off-market, subleases, future availability)
Alone or With Other Brokers
- Managing agents owe a fiduciary duty to landlords, seeking maximum price and terms rather than tenant savings.
- Inherent conflict of interest as most brokers represent landlords
- Risk of weaker terms and overlooked hidden costs
- Heavy workload falls on you while best spaces are missed
About SoHo
Geographic Boundaries of SoHo, NYC
SoHo, short for "South of Houston Street," is a distinct neighborhood located in Lower Manhattan, New York City. It is roughly bounded by Houston Street to the north, Canal Street to the south, Crosby Street to the east, and Sixth Avenue (Avenue of the Americas) to the west. These boundaries place SoHo directly south of Greenwich Village and north of the Civic Center and Tribeca neighborhoods. The area lies mainly within Manhattan Community District 2 and covers parts of ZIP Codes 10012 and 10013. The neighborhood is known for its historic district designation, incorporating about 26 blocks and approximately 500 buildings, many with characteristic cast-iron façades.Description of Businesses, Stores, Retailers, and Fine Restaurants
SoHo has evolved into a premier destination for shopping, dining, and cultural experiences. The neighborhood showcases a blend of upscale boutiques, international brand flagship stores, and unique smaller retailers. Visitors and residents alike can find luxury fashion brands alongside contemporary and trendy clothing shops, art galleries, and design stores. The streets buzz with both haute couture priced like fine art and accessible fast fashion outlets, making it a versatile shopping environment. In addition to retail, SoHo boasts a rich culinary scene. The neighborhood features numerous fine dining restaurants ranging from elegant French bistros and modern American eateries to innovative international cuisine. Many establishments maintain a chic, stylish atmosphere befitting the area's artistic heritage. Sidewalk cafés and trendy bars complement the dining scene, offering vibrant nightlife options that contribute to SoHo's reputation as a lively, upscale urban neighborhood.History of Major Attractions in SoHo, NYC
SoHo's history is a classic example of urban regeneration and gentrification. Initially, it was an industrial area characterized by warehouses and manufacturing, especially related to textiles. In the mid-20th century, many factories closed, leaving large loft spaces empty. Artists seeking affordable spaces converted these industrial buildings into live-work lofts beginning in the 1960s and 1970s, establishing SoHo as a creative hub. The neighborhood gained its name in 1962 from urban planner Chester Rapkin, who coined "SoHo" to describe the "South of Houston Street" area. Its recognition as an artistic enclave grew, supported by the architectural uniqueness of cast-iron buildings, allowing for large open interiors ideal for studios and galleries. The SoHo–Cast Iron Historic District was designated in 1973 and extended in 2010 to preserve its distinctive buildings and character. It was also declared a National Historic Landmark in 1978. Over time, SoHo transitioned from an artist community to a fashionable residential and commercial district, with its historical significance and cast-iron architecture serving as major attractions alongside art galleries, cobblestone streets, and vibrant cultural life.Types of Buildings and Other Significant Buildings
SoHo is internationally renowned for its cast-iron architecture. Many buildings were constructed in the late 19th century using cast iron for both structural and decorative elements. This architectural style allowed for large windows and open interiors that were particularly suited to industrial use and later ideal for artists’ lofts. The streets are paved with historic Belgian blocks, adding to the neighborhood's charm. Key notable buildings include landmarks such as the Haughwout Building, famous for its elaborate cast-iron façade, and the E. V. Haughwout Building, which houses one of the earliest passenger elevators. The neighborhood also contains historic warehouses and former factories now converted into residential lofts, art galleries, and retail spaces. The cast-iron elements contribute both to SoHo’s aesthetic appeal and its historical value.Transportation Options
SoHo is well served by multiple public transportation options, facilitating convenient access to and from the neighborhood. The New York City Subway has several stations nearby, including the Broadway-Lafayette Street station (serving the B, D, F, M lines), the Canal Street stations (serving various lines such as the 1, 2, 3, A, C, E, N, Q, R, and W), and the Spring Street station (serving the 6 line). Numerous bus routes also run through the area, connecting SoHo with other parts of Manhattan and the greater NYC area. Additionally, SoHo’s pedestrian-friendly layout, with cobblestone streets and plazas, encourages walking and biking, making it easy for residents and visitors to explore the neighborhood’s shops, galleries, and restaurants on foot or by bike.Adjacent ZIP Codes and Neighborhoods
SoHo primarily falls within the 10012 and 10013 ZIP Codes. Surrounding neighborhoods include Greenwich Village to the north and northwest, the East Village slightly northeast across Houston Street, Tribeca to the southwest, and the Civic Center area to the south. The proximity to these diverse and well-known neighborhoods enhances SoHo’s accessibility and appeal within Lower Manhattan.Prominent Companies and Types of Businesses with Offices in SoHo
SoHo hosts a range of businesses that reflect its creative and commercial identity. The neighborhood is home to many design firms, fashion brands, and media companies, which often take advantage of the loft spaces and historic buildings for their offices and showrooms. These businesses include cutting-edge technology startups, boutique advertising agencies, contemporary art galleries, and lifestyle brands. Fashion companies, both established labels and emerging designers, maintain flagship stores and corporate offices in SoHo, contributing to the district’s reputation as a fashion capital. Additionally, creative industries such as graphic design, digital media, and marketing agencies have established offices here, leveraging SoHo’s cultural cachet and central location. This mix of retail, creative services, and tech-oriented businesses reinforces SoHo’s role as a dynamic, multifaceted neighborhood. --- SoHo, Manhattan, thus combines rich historical architecture and cultural heritage with a vibrant present-day scene of high-end retail, fine dining, and creative businesses, all within a distinctive urban fabric shaped by its geographic positioning and transportation connectivity.Office Buildings in SoHo
- 195-197 Chrystie Street
- 561 Broadway
- 195-199 Lafayette Street
- 379 West Broadway
- 67-73 Spring Street
- 120 Wooster Street
- 128-138 Mott Street
- 64-68 Wooster Street
- 166 Mercer
- 96 Spring Street
- 36-44 Delancey Street
- 434 Broadway
- 107 Grand Street
- 210 Elizabeth St
- 40 Crosby St
- 75 Spring Street
- 132-138 Mulberry Street